Cleaving Double-Stranded DNA with Peptide Nucleic Acids

David J. Ecker (Inventor), Ole Buchardt (Inventor), Michael Engholm (Inventor), Peter E. Nielsen (Inventor), Rolf Henrik Berg (Inventor), Niels E. Møllegaard (Inventor)

    Research output: Patent

    72 Downloads (Pure)


    Peptide nucleic acids and analogues of peptide nucleic acids are used to form duplex, triplex, and other structures with nucleic acids and to modify nucleic acids. The peptide nucleic acids and analogues thereof also are used to modulate protein activity through, for example, transcription arrest, transcription initiation, and site specific cleavage of nucleic acids.
    Original languageEnglish
    Patent numberUS5641625
    Filing date24/06/1997
    Publication statusPublished - 1997

    Bibliographical note

    Also published as: WO9501370 (A1) US5986053 (A) JPH09503198 (A) JPH11236396 (A) ES2187527 (T3) EP0776331 (A1) EP0776331 (A4) EP0776331 (B1) DK0776331 (T3) DE69431805 (T2) CA2166461 (A1) AT228534 (T)


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