Classical swine fever virus infection modulates serum levels of INF-α, IL-8 and TNF-α in 6-month-old pigs

Tanya von Rosen, Louise Lohse, Jens Nielsen, Åse Uttenthal

    Research output: Contribution to journalJournal articleResearchpeer-review

    1 Downloads (Pure)

    Abstract

    Several studies have highlighted the important role of cytokines in disease development of classical swine fever virus (CSFV) infection. In the present study, we examined the kinetics of 7 porcine cytokines in serum from pigs infected with 3 different CSFV strains. Based on the clinical picture in 6-month-old Danish pigs, the strains used for inoculation were classified as being of low (Bergen), low to moderate (Eystrup) and moderate to high (Lithuania) virulence. The cytokines interferon-alpha (INF-α), interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-α) showed increased levels after CSFV infection with more or less comparable course in the 3 groups. However, the cytokine level peaked with a 2–3 days delay in pigs infected with the low virulent strain compared to those infected with a moderately or highly virulent strain. These findings may indicate that INF-α, IL-8 and TNF-α are involved in the immune response during CSFV infection with strains of different virulence.
    Original languageEnglish
    JournalResearch in Veterinary Science
    Volume95
    Issue number3
    Pages (from-to)1262–1267
    ISSN0034-5288
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Cytokines
    • Pigs
    • Classical swine fever virus
    • Pathogenesis
    • Virulence
    • Pestivirus

    Fingerprint Dive into the research topics of 'Classical swine fever virus infection modulates serum levels of INF-α, IL-8 and TNF-α in 6-month-old pigs'. Together they form a unique fingerprint.

    Cite this