Cladobotryal: a Fungal Metabolite with a Novel Ring System

Jens Breinholt; Helle C. Jensen; Anders Kjær; Carl E. Olsen; Birgitte R. Rassing; Connie N. Rosendahl; Inger Søtofte

Cladobotryal: a Fungal Metabolite with a Novel Ring System

Jens Breinholt, Helle C. Jensen, Anders Kjær, Carl E. Olsen, Birgitte R. Rassing, Connie N. Rosendahl, Inger Søtofte

Department of Chemistry

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

In screening for antifungal metabolites a novel compound, cladobotryal, was isolated from the mycoparasitic fungus Cladobotryum varium. Its structure was established as (+)-(2R*,3R*)-2-[(Z)- 2-buten-2-yl]-3,7-dihydro-3-formyl-3-methyl-5-phenylfuro[2,3-b]pyr idin-4(2H)-one on the basis of spectroscopic evidence and single crystal X-ray analysis of its methyl hemiacetal. The fused furo[2,3-b]pyridinone skeleton of cladobotryal seems unprecedented within the chemical literature.

Original language	English
Journal	Acta Chemica Scandinavica
Volume	52
Pages (from-to)	631-634
Publication status	Published - 1998

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title = "Cladobotryal: a Fungal Metabolite with a Novel Ring System",

abstract = "In screening for antifungal metabolites a novel compound, cladobotryal, was isolated from the mycoparasitic fungus Cladobotryum varium. Its structure was established as (+)-(2R*,3R*)-2-[(Z)- 2-buten-2-yl]-3,7-dihydro-3-formyl-3-methyl-5-phenylfuro[2,3-b]pyr idin-4(2H)-one on the basis of spectroscopic evidence and single crystal X-ray analysis of its methyl hemiacetal. The fused furo[2,3-b]pyridinone skeleton of cladobotryal seems unprecedented within the chemical literature.",

author = "Jens Breinholt and Jensen, {Helle C.} and Anders Kj{\ae}r and Olsen, {Carl E.} and Rassing, {Birgitte R.} and Rosendahl, {Connie N.} and Inger S{\o}tofte",

year = "1998",

language = "English",

volume = "52",

pages = "631--634",

journal = "Acta Chemica Scandinavica",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Cladobotryal: a Fungal Metabolite with a Novel Ring System

AU - Breinholt, Jens

AU - Jensen, Helle C.

AU - Kjær, Anders

AU - Olsen, Carl E.

AU - Rassing, Birgitte R.

AU - Rosendahl, Connie N.

AU - Søtofte, Inger

PY - 1998

Y1 - 1998

N2 - In screening for antifungal metabolites a novel compound, cladobotryal, was isolated from the mycoparasitic fungus Cladobotryum varium. Its structure was established as (+)-(2R*,3R*)-2-[(Z)- 2-buten-2-yl]-3,7-dihydro-3-formyl-3-methyl-5-phenylfuro[2,3-b]pyr idin-4(2H)-one on the basis of spectroscopic evidence and single crystal X-ray analysis of its methyl hemiacetal. The fused furo[2,3-b]pyridinone skeleton of cladobotryal seems unprecedented within the chemical literature.

AB - In screening for antifungal metabolites a novel compound, cladobotryal, was isolated from the mycoparasitic fungus Cladobotryum varium. Its structure was established as (+)-(2R*,3R*)-2-[(Z)- 2-buten-2-yl]-3,7-dihydro-3-formyl-3-methyl-5-phenylfuro[2,3-b]pyr idin-4(2H)-one on the basis of spectroscopic evidence and single crystal X-ray analysis of its methyl hemiacetal. The fused furo[2,3-b]pyridinone skeleton of cladobotryal seems unprecedented within the chemical literature.

M3 - Journal article

VL - 52

SP - 631

EP - 634

JO - Acta Chemica Scandinavica

JF - Acta Chemica Scandinavica

ER -