Cladobotryal: a Fungal Metabolite with a Novel Ring System

Jens Breinholt, Helle C. Jensen, Anders Kjær, Carl E. Olsen, Birgitte R. Rassing, Connie N. Rosendahl, Inger Søtofte

Research output: Contribution to journalJournal articleResearchpeer-review


In screening for antifungal metabolites a novel compound, cladobotryal, was isolated from the mycoparasitic fungus Cladobotryum varium. Its structure was established as (+)-(2R*,3R*)-2-[(Z)- 2-buten-2-yl]-3,7-dihydro-3-formyl-3-methyl-5-phenylfuro[2,3-b]pyr idin-4(2H)-one on the basis of spectroscopic evidence and single crystal X-ray analysis of its methyl hemiacetal. The fused furo[2,3-b]pyridinone skeleton of cladobotryal seems unprecedented within the chemical literature.
Original languageEnglish
JournalActa Chemica Scandinavica
Pages (from-to)631-634
Publication statusPublished - 1998

Cite this