Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (Serum CTx): Effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting

P. Qvist, S. Christgau, Brian Juel Pedersen, A. Schlemmer, C. Christiansen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We examined the diurnal variation in serum concentration of C-terminal telopeptide of type I collagen (serum CrossLaps, sCTx) under various conditions. The studies included a total of 100 individuals. Blood samples were collected every 3 h over 27 h. sCTx levels varied over the 24 h with a maximum at about 05:00 in the morning and a minimum of about 14:00 in the afternoon. The variation had a magnitude of about +/-40% around the 24 h mean and was similar in premenopausal and early and late postmenopausal women with normal and low bone mass. Furthermore, it was not affected by 5 days of bed-rest, by absence of a normal diurnal variation in cortisol production, or by absence of a normal light cycle (blindness). Nasal salmon calcitonin, an antiresorptive drug used for treatment of osteoporosis, was not able to break the circadian pattern whether the treatment was administered in the morning or the evening. The only parameter that showed a pronounced influence on the circadian variation was fasting, which reduced the variation significantly to about one fourth. From a practical point of view the results of this study demonstrate that samples for sCTx should be taken in the fasting state.
Original languageEnglish
JournalThe Bone
Volume31
Issue number1
Pages (from-to)57-61
ISSN0914-7047
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Adult
  • Age Factors
  • Aged
  • Analysis of Variance
  • Circadian Rhythm
  • Collagen
  • Collagen Type I
  • Fasting
  • Female
  • Humans
  • Hydrocortisone
  • Male
  • Menopause
  • Middle Aged
  • Peptide Fragments
  • Peptides
  • Posture
  • Regression Analysis
  • Sex Factors
  • collagen type I trimeric cross-linked peptide
  • glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine
  • 9007-34-5 Collagen
  • WI4X0X7BPJ Hydrocortisone
  • carboxy terminal telopeptide
  • collagen type 1
  • hydrocortisone
  • protein
  • salcatonin
  • unclassified drug
  • adult
  • age
  • aged
  • article
  • bed rest
  • blindness
  • blood sampling
  • body posture
  • bone mass
  • circadian rhythm
  • concentration (parameters)
  • controlled study
  • diet restriction
  • female
  • gender
  • hormone determination
  • hormone synthesis
  • human
  • human experiment
  • hydrocortisone blood level
  • menopause
  • night
  • osteoporosis
  • postmenopause
  • premenopause
  • protein blood level
  • protein determination
  • sunlight
  • time
  • Bone markers
  • Bone turnover
  • C-terminal telopeptide of type I collagen (sCTx)
  • Circadian variation
  • Diurnal variation
  • Serum CTx
  • ENDOCRINOLOGY
  • EARLY POSTMENOPAUSAL WOMEN
  • LINKED N-TELOPEPTIDES
  • ONE-STEP ELISA
  • DEGRADATION PRODUCTS
  • BIOCHEMICAL MARKERS
  • BONE-RESORPTION
  • MONOCLONAL-ANTIBODIES
  • URINARY-EXCRETION
  • DIURNAL-VARIATION
  • CROSS-LINKS
  • bone markers
  • bone turnover
  • serum CTx
  • diurnal variation
  • circadian variation
  • age effect
  • daylight effect
  • fasting
  • gender effect
  • menopausal status
  • posture
  • Primates Mammalia Vertebrata Chordata Animalia (Animals, Chordates, Humans, Mammals, Primates, Vertebrates) - Hominidae [86215] human
  • cortisol 50-23-7
  • type I collagen C-terminal telopeptide
  • 07200, Circadian rhythms and other periodic cycles
  • 10006, Clinical biochemistry - General methods and applications
  • 10064, Biochemistry studies - Proteins, peptides and amino acids
  • 10067, Biochemistry studies - Sterols and steroids
  • 15002, Blood - Blood and lymph studies
  • 15004, Blood - Blood cell studies
  • Allied Medical Sciences
  • serum blood and lymphatics
  • Biosynchronization
  • Clinical Chemistry

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