TY - JOUR
T1 - Ciprofloxacin-loaded sodium alginate/poly (lactic-co-glycolic acid) electrospun fibrous mats for wound healing
AU - Liu, Xiaoli
AU - Nielsen, Line Hagner
AU - Klodzinska, Sylvia Natalie
AU - Nielsen, Hanne Mørck
AU - Qu, Haiyan
AU - Christensen, Lars Porskjær
AU - Rantanen, Jukka
AU - Yang, Mingshi
PY - 2017
Y1 - 2017
N2 - Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to prevent infections. Until now, none of the existing wound dressing products can meet all these requirements. To design a wound dressing with as many of the aforementioned features as possible, in this study, we attempted to prepare ciprofloxacin (CIP), an antibiotic, loaded electrospun hydrophobic poly (lactic-co-glycolic acid) (PLGA) fibrous mats modified with hydrophilic sodium alginate (ALG) microparticles. The results showed that ALG could improve the wettability, water absorption capacity, and enhance the release rate of ciprofloxacin from the PLGA fibrous mats. In addition, the addition of ALG reduced the stiffness of PLGA fibrous mats for better protection of the injured area as indicated by the Young's Modulus. Moreover, the burst release of CIP resulted from the addition of ALG seemed to provide an improved antibacterial effect to the PLGA mats. This study demonstrated the potential of combining hydrophilic and hydrophobic polymers to design the desired wound dressings via the electrospinning process.
AB - Wound dressings should ideally be able to maintain high humidity, remove excess wound exudate, permit thermal insulation, provide certain mechanical strength, and in some cases deliver antibiotics to prevent infections. Until now, none of the existing wound dressing products can meet all these requirements. To design a wound dressing with as many of the aforementioned features as possible, in this study, we attempted to prepare ciprofloxacin (CIP), an antibiotic, loaded electrospun hydrophobic poly (lactic-co-glycolic acid) (PLGA) fibrous mats modified with hydrophilic sodium alginate (ALG) microparticles. The results showed that ALG could improve the wettability, water absorption capacity, and enhance the release rate of ciprofloxacin from the PLGA fibrous mats. In addition, the addition of ALG reduced the stiffness of PLGA fibrous mats for better protection of the injured area as indicated by the Young's Modulus. Moreover, the burst release of CIP resulted from the addition of ALG seemed to provide an improved antibacterial effect to the PLGA mats. This study demonstrated the potential of combining hydrophilic and hydrophobic polymers to design the desired wound dressings via the electrospinning process.
KW - Antimicrobial activity
KW - Electrospinning
KW - Hydrodynamic methods
KW - Hydrophilicity
KW - Mechanical properties
KW - Water-solid interactions
U2 - 10.1016/j.ejpb.2017.11.004
DO - 10.1016/j.ejpb.2017.11.004
M3 - Journal article
C2 - 29129734
SN - 0939-6411
VL - 123
SP - 42
EP - 49
JO - European Journal of Pharmaceutics and Biopharmaceutics
JF - European Journal of Pharmaceutics and Biopharmaceutics
ER -