Chlorinated Iridoid Glucosides from Veronica longifolia and their Antioxidant Activity

Søren Rosendal Jensen, Charlotte Held Gotfredsen, U. Sebnem Harput, Iclal Saracoglu

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From Veronica longifolia were isolated three chlorinated iridoid glucosides, namely asystasioside E (6) and its 6-O-esters 6a and 6b, named longifoliosides A and B, respectively. The structures of 6a and 6b were proved by analysis of their spectroscopic data and by conversion to the catalpol ester verproside (5a) or to catalpol (5), respectively. The configuration of the previously known vanilloyl analogue, urphoside B, was shown to be the 6-epimer (6c) of the structure originally reported. Longifoliosides A (6a) and B (6b) were found to exhibit radical-scavenging activity against nitric oxide (NO), superoxide (SO), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.
Original languageEnglish
JournalJournal of Natural Products
Issue number9
Pages (from-to)1593-1596
Publication statusPublished - 2010


  • Veronica longifolia
  • Iridoid glucoside
  • Longifoliosides A and B
  • Plantaginaceae
  • radical-scavenging activity


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