Chiral amplification of oligopeptides in two-dimensional crystalline self-assemblies on water

H. Zepik, E. Shavit, M. Tang, T.R. Jensen, K. Kjær, G. Bolbach, L. Leiserowitz, I. Weissbuch, M. Lahav

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    Differences in the two-dimensional packing arrangements of racemic and enantiomeric crystalline self-assemblies on the water surface of amphiphilic activated analogs of lysine and glutamic acid have been used to prepare oligopeptides of homochiral sequence and oligopeptides of single handedness from chiral nonracemic mixtures. The crystalline structures on the water surface were determined by grazing incidence x-ray diffraction and the diastereomeric composition of the oligopeptides by matrix-assisted laser desorption time-of-flight mass spectrometry with enantio-labeling. These results suggest that reactivity of ordered clusters at interfaces might have played a role in the generation of early homochiral biopolymers.
    Original languageEnglish
    JournalScience
    Volume295
    Issue number5558
    Pages (from-to)1266-1269
    ISSN0036-8075
    DOIs
    Publication statusPublished - 2002

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