Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor

Frederik Westergaard Østerberg; Bjarke Thomas Dalslet; Detlef Snakenborg; Christer Johansson; Mikkel Fougt Hansen

Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor

Frederik Westergaard Østerberg, Bjarke Thomas Dalslet, Detlef Snakenborg, Christer Johansson, Mikkel Fougt Hansen

Imego AB

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Abstract

We present a simple 'click-on' fluidic system with integrated electrical contacts, which is suited for electrical measurements on chips in microfluidic systems. We show that microscopic magnetic field sensors based on the planar Hall effect can be used for detecting the complex magnetic response using only the self-field arising from the bias current applied to the sensors as excitation field. We present measurements on a suspension of magnetic beads with a nominal diameter of 250 nm vs. temperature and find that the observations are consistent with the Cole-Cole model for Brownian relaxation with a constant hydrodynamic bead diameter when the temperature dependence of the viscosity of water is taken into account. These measurements demonstrate the feasibility of performing measurements of the Brownian relaxation response in a lab-on-a-chip system and constitute the first step towards an integrated biosensor based on the detection of the dynamic response of magnetic beads.

Original language	English
Title of host publication	8. INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS
Publication date	2010
Pages	176-183
Publication status	Published - 2010
Event	8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers - Rostock, Germany Duration: 25 May 2010 → 29 May 2010 Conference number: 8

Conference

Conference	8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers
Number	8
Country/Territory	Germany
City	Rostock
Period	25/05/2010 → 29/05/2010

Series	AIP Conference Proceedings
Number	1311
ISSN	0094-243X

Keywords

Magnetorelaxometry
Lab-on-a-chip
Brownian relaxation
Planar Hall effect

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title = "Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor",

abstract = "We present a simple 'click-on' fluidic system with integrated electrical contacts, which is suited for electrical measurements on chips in microfluidic systems. We show that microscopic magnetic field sensors based on the planar Hall effect can be used for detecting the complex magnetic response using only the self-field arising from the bias current applied to the sensors as excitation field. We present measurements on a suspension of magnetic beads with a nominal diameter of 250 nm vs. temperature and find that the observations are consistent with the Cole-Cole model for Brownian relaxation with a constant hydrodynamic bead diameter when the temperature dependence of the viscosity of water is taken into account. These measurements demonstrate the feasibility of performing measurements of the Brownian relaxation response in a lab-on-a-chip system and constitute the first step towards an integrated biosensor based on the detection of the dynamic response of magnetic beads.",

keywords = "Magnetorelaxometry, Lab-on-a-chip, Brownian relaxation, Planar Hall effect",

author = "{\O}sterberg, {Frederik Westergaard} and Dalslet, {Bjarke Thomas} and Detlef Snakenborg and Christer Johansson and Hansen, {Mikkel Fougt}",

year = "2010",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics",

number = "1311",

pages = "176--183",

booktitle = "8. INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS",

note = "8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, SCAMC ; Conference date: 25-05-2010 Through 29-05-2010",

}

Østerberg, FW, Dalslet, BT, Snakenborg, D, Johansson, C & Hansen, MF 2010, Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor. in 8. INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS. AIP Conference Proceedings, no. 1311, pp. 176-183, 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Rostock, Germany, 25/05/2010.

Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor. / Østerberg, Frederik Westergaard; Dalslet, Bjarke Thomas; Snakenborg, Detlef et al.
8. INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS. 2010. p. 176-183 (AIP Conference Proceedings; No. 1311).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor

AU - Østerberg, Frederik Westergaard

AU - Dalslet, Bjarke Thomas

AU - Snakenborg, Detlef

AU - Johansson, Christer

AU - Hansen, Mikkel Fougt

N1 - Conference code: 8

PY - 2010

Y1 - 2010

N2 - We present a simple 'click-on' fluidic system with integrated electrical contacts, which is suited for electrical measurements on chips in microfluidic systems. We show that microscopic magnetic field sensors based on the planar Hall effect can be used for detecting the complex magnetic response using only the self-field arising from the bias current applied to the sensors as excitation field. We present measurements on a suspension of magnetic beads with a nominal diameter of 250 nm vs. temperature and find that the observations are consistent with the Cole-Cole model for Brownian relaxation with a constant hydrodynamic bead diameter when the temperature dependence of the viscosity of water is taken into account. These measurements demonstrate the feasibility of performing measurements of the Brownian relaxation response in a lab-on-a-chip system and constitute the first step towards an integrated biosensor based on the detection of the dynamic response of magnetic beads.

AB - We present a simple 'click-on' fluidic system with integrated electrical contacts, which is suited for electrical measurements on chips in microfluidic systems. We show that microscopic magnetic field sensors based on the planar Hall effect can be used for detecting the complex magnetic response using only the self-field arising from the bias current applied to the sensors as excitation field. We present measurements on a suspension of magnetic beads with a nominal diameter of 250 nm vs. temperature and find that the observations are consistent with the Cole-Cole model for Brownian relaxation with a constant hydrodynamic bead diameter when the temperature dependence of the viscosity of water is taken into account. These measurements demonstrate the feasibility of performing measurements of the Brownian relaxation response in a lab-on-a-chip system and constitute the first step towards an integrated biosensor based on the detection of the dynamic response of magnetic beads.

KW - Magnetorelaxometry

KW - Lab-on-a-chip

KW - Brownian relaxation

KW - Planar Hall effect

M3 - Article in proceedings

T3 - AIP Conference Proceedings

SP - 176

EP - 183

BT - 8. INTERNATIONAL CONFERENCE ON THE SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS

T2 - 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers

Y2 - 25 May 2010 through 29 May 2010

ER -

Chip-Based Measurements of Brownian Relaxation of Magnetic Beads Using a Planar Hall Effect Magnetic Field Sensor

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