ChemProt: a disease chemical biology database

Olivier Taboureau, Sonny Kim Nielsen, Karine Marie Laure Audouze, Nils Weinhold, Stefan Daniel Edsgard, francisco jose sousa simôes almeida Roque, Irene Kouskoumvekaki, A. Bora, R. Curpan, Thomas Skøt Jensen, Søren Brunak, Tudor Oprea

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    Systems pharmacology is an emergent area that studies drug action across multiple scales of complexity, from molecular and cellular to tissue and organism levels. There is a critical need to develop network-based approaches to integrate the growing body of chemical biology knowledge with network biology. Here, we report ChemProt, a disease chemical biology database, which is based on a compilation of multiple chemical-protein annotation resources, as well as disease-associated protein-protein interactions (PPIs). We assembled more than 700 000 unique chemicals with biological annotation for 30 578 proteins. We gathered over 2-million chemical-protein interactions, which were integrated in a quality scored human PPI network of 428 429 interactions. The PPI network layer allows for studying disease and tissue specificity through each protein complex. ChemProt can assist in the in silico evaluation of environmental chemicals, natural products and approved drugs, as well as the selection of new compounds based on their activity profile against most known biological targets, including those related to adverse drug events. Results from the disease chemical biology database associate citalopram, an antidepressant, with osteogenesis imperfect and leukemia and bisphenol A, an endocrine disruptor, with certain types of cancer, respectively. The server can be accessed at
    Original languageEnglish
    JournalNucleic Acids Research
    Issue numberIssue Suppl. 1
    Pages (from-to)D367-372
    Publication statusPublished - 2011

    Bibliographical note

    This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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