TY - JOUR
T1 - Chemoselective Transfer Hydrogenation of Enamides Using Ru Pincer Complexes for the Synthesis of α-Amino Acids
AU - Pinheiro, Danielle L. J.
AU - Nielsen, Martin
PY - 2022
Y1 - 2022
N2 - The chemoselective reduction of enamides to α-amino acids with iPrOH and EtOH as H-donors and solvents catalyzed by Ru pincer complexes is demonstrated. A range of α-amino acids is synthesized in good to excellent yields. Applications, large scale, and a one-pot experiment are also reported. Finally, deuterium-labeling experiments show high regioselectivity between the α- and β-positions of the alkene unit.
AB - The chemoselective reduction of enamides to α-amino acids with iPrOH and EtOH as H-donors and solvents catalyzed by Ru pincer complexes is demonstrated. A range of α-amino acids is synthesized in good to excellent yields. Applications, large scale, and a one-pot experiment are also reported. Finally, deuterium-labeling experiments show high regioselectivity between the α- and β-positions of the alkene unit.
U2 - 10.1021/acs.joc.1c02975
DO - 10.1021/acs.joc.1c02975
M3 - Journal article
C2 - 35213167
SN - 0022-3263
VL - 87
SP - 5419
EP - 5423
JO - Journal of organic chemistry
JF - Journal of organic chemistry
IS - 8
ER -