Chemistry and Biology of Natural Azoxy Compounds

Mario Wibowo*, Ling Ding

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Azoxy compounds belong to a small yet intriguing group of natural products sharing a common functional group with the general structure RN═N+(O)R. Their intriguing chemical structures, diverse biological activities, and important industrial applications have received attention from researchers in natural product chemistry, total synthesis, and biosynthesis. This review presents current updates about the structural diversity of natural azoxy compounds isolated from different organisms and highlights the enzymes and biological logic involved in their construction. We assume that the identification of key enzymes will provide efficient tools in biocatalysis to generate new azoxy compounds, while genome mining may result in novel natural azoxy compounds of medical and industrial interest.
Original languageEnglish
Article number10
JournalJournal of Natural Products
Issue number11
Pages (from-to)3482-3491
Publication statusPublished - 2020


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