Chemically induced hypothyroidism disrupts neuronal migration, parvalbumin-positive interneurons and oligodendrocyte-astrocyte differentiation in the developing rat brain

Louise Ramhøj; Jacob Ardenkjær-Skinnerup; Marie Berg; Nichlas Davidsen; Marta Axelstad; Terje Svingen

Chemically induced hypothyroidism disrupts neuronal migration, parvalbumin-positive interneurons and oligodendrocyte-astrocyte differentiation in the developing rat brain

Louise Ramhøj^*
, Jacob Ardenkjær-Skinnerup
, Marie Berg
, Nichlas Davidsen
, Marta Axelstad
, Terje Svingen

^*Corresponding author for this work

Research output: Contribution to conference › Poster › Research › peer-review

Abstract

Thyroid hormone (TH) system-disrupting chemicals can induce developmental hypothyroidism and disrupt TH-dependent brain development. Here we investigated the effects of thyroperoxidase (TPO)-inhibiting compounds methimazole (MMI, medical drug) and amitrole (herbicide) on the developing brain.

Original language	English
Publication date	2025
Number of pages	1
Publication status	Published - 2025
Event	17th International Thyroid Congress - Rio de Janeiro Duration: 18 Jun 2025 → 22 Jun 2025

Conference

Conference	17th International Thyroid Congress
City	Rio de Janeiro
Period	18/06/2025 → 22/06/2025

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Chemically induced hypothyroidism disrupts neuronal migration, parvalbumin-positive interneurons and oligodendrocyte-astrocyte differentiation in the developing rat brain
Ramhøj, L., Ardenkjær-Skinnerup, J., Berg, M., Davidsen, N., Axelstad, M. & Svingen, T., 2025. 1 p.
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Cite this

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title = "Chemically induced hypothyroidism disrupts neuronal migration, parvalbumin-positive interneurons and oligodendrocyte-astrocyte differentiation in the developing rat brain",

abstract = "Thyroid hormone (TH) system-disrupting chemicals can induce developmental hypothyroidism and disrupt TH-dependent brain development. Here we investigated the effects of thyroperoxidase (TPO)-inhibiting compounds methimazole (MMI, medical drug) and amitrole (herbicide) on the developing brain.",

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Chemically induced hypothyroidism disrupts neuronal migration, parvalbumin-positive interneurons and oligodendrocyte-astrocyte differentiation in the developing rat brain. / Ramhøj, Louise ; Ardenkjær-Skinnerup, Jacob ; Berg, Marie et al.
2025. Poster session presented at 17th International Thyroid Congress, Rio de Janeiro.

Research output: Contribution to conference › Poster › Research › peer-review

TY - CONF

T1 - Chemically induced hypothyroidism disrupts neuronal migration, parvalbumin-positive interneurons and oligodendrocyte-astrocyte differentiation in the developing rat brain

AU - Ramhøj, Louise

AU - Ardenkjær-Skinnerup, Jacob

AU - Berg, Marie

AU - Davidsen, Nichlas

AU - Axelstad, Marta

AU - Svingen, Terje

PY - 2025

Y1 - 2025

N2 - Thyroid hormone (TH) system-disrupting chemicals can induce developmental hypothyroidism and disrupt TH-dependent brain development. Here we investigated the effects of thyroperoxidase (TPO)-inhibiting compounds methimazole (MMI, medical drug) and amitrole (herbicide) on the developing brain.

AB - Thyroid hormone (TH) system-disrupting chemicals can induce developmental hypothyroidism and disrupt TH-dependent brain development. Here we investigated the effects of thyroperoxidase (TPO)-inhibiting compounds methimazole (MMI, medical drug) and amitrole (herbicide) on the developing brain.

M3 - Poster

T2 - 17th International Thyroid Congress

Y2 - 18 June 2025 through 22 June 2025

ER -

Chemically induced hypothyroidism disrupts neuronal migration, parvalbumin-positive interneurons and oligodendrocyte-astrocyte differentiation in the developing rat brain

Abstract

Conference

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Research output

Chemically induced hypothyroidism disrupts neuronal migration, parvalbumin-positive interneurons and oligodendrocyte-astrocyte differentiation in the developing rat brain

Cite this