TY - JOUR
T1 - Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants
AU - Johansson, Hanna Katarina Lilith
AU - Boberg, Julie
AU - Dybdahl, Marianne
AU - Axelstad, Marta
AU - Vinggaard, Anne Marie
PY - 2019
Y1 - 2019
N2 - Today, detailed risk assessment can only be performed for a few percent of the total number of current-use chemicals because of lack of data. Toxicity data is, therefore, needed for a substantial number of untested chemicals, a task that requires improved and faster chemical risk assessment strategies that are cost-efficient, human relevant and ethically responsible. In this commentary, we use a case study on five known thyroid toxic chemicals (perfluorooctanesulfonic acid, triclosan, tetrabromobisphenol A, decabromodiphenyl ether and hexabromocyclododecane) to explore the use of in vitro data for hazard assessment together with human biomonitoring (HBM) data for exposure assessment when evaluating human risk. Based on the case study, we conclude that in vitro and HBM data can be used for risk ranking of chemicals. We envision that an in vitro/HBM approach can use data from studies such as the big European initiative Human Biomonitoring for Europe (HBM4EU) together with human-relevant in vitro data to make alternative risk assessment more valuable to finally be able to ‘stand-alone’.
AB - Today, detailed risk assessment can only be performed for a few percent of the total number of current-use chemicals because of lack of data. Toxicity data is, therefore, needed for a substantial number of untested chemicals, a task that requires improved and faster chemical risk assessment strategies that are cost-efficient, human relevant and ethically responsible. In this commentary, we use a case study on five known thyroid toxic chemicals (perfluorooctanesulfonic acid, triclosan, tetrabromobisphenol A, decabromodiphenyl ether and hexabromocyclododecane) to explore the use of in vitro data for hazard assessment together with human biomonitoring (HBM) data for exposure assessment when evaluating human risk. Based on the case study, we conclude that in vitro and HBM data can be used for risk ranking of chemicals. We envision that an in vitro/HBM approach can use data from studies such as the big European initiative Human Biomonitoring for Europe (HBM4EU) together with human-relevant in vitro data to make alternative risk assessment more valuable to finally be able to ‘stand-alone’.
KW - Environmental chemicals
KW - Human biomonitoring
KW - In vitro
KW - PFOS
KW - Risk assessment
KW - Thyroid toxicity
U2 - 10.1016/j.cotox.2018.12.001
DO - 10.1016/j.cotox.2018.12.001
M3 - Journal article
SN - 2468-2020
VL - 15
SP - 8
EP - 17
JO - Current Opinion in Toxicology
JF - Current Opinion in Toxicology
ER -