Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

Hanna Katarina Lilith Johansson, Julie Boberg, Marianne Dybdahl, Marta Axelstad, Anne Marie Vinggaard*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Today, detailed risk assessment can only be performed for a few percent of the total number of current-use chemicals because of lack of data. Toxicity data is, therefore, needed for a substantial number of untested chemicals, a task that requires improved and faster chemical risk assessment strategies that are cost-efficient, human relevant and ethically responsible. In this commentary, we use a case study on five known thyroid toxic chemicals (perfluorooctanesulfonic acid, triclosan, tetrabromobisphenol A, decabromodiphenyl ether and hexabromocyclododecane) to explore the use of in vitro data for hazard assessment together with human biomonitoring (HBM) data for exposure assessment when evaluating human risk. Based on the case study, we conclude that in vitro and HBM data can be used for risk ranking of chemicals. We envision that an in vitro/HBM approach can use data from studies such as the big European initiative Human Biomonitoring for Europe (HBM4EU) together with human-relevant in vitro data to make alternative risk assessment more valuable to finally be able to ‘stand-alone’.
Original languageEnglish
JournalCurrent Opinion in Toxicology
Volume15
Pages (from-to)8-17
ISSN2468-2020
DOIs
Publication statusPublished - 2019

Keywords

  • Environmental chemicals
  • Human biomonitoring
  • In vitro
  • PFOS
  • Risk assessment
  • Thyroid toxicity

Cite this

@article{0012fc6b63734befbfe72f724ffc9d51,
title = "Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants",
abstract = "Today, detailed risk assessment can only be performed for a few percent of the total number of current-use chemicals because of lack of data. Toxicity data is, therefore, needed for a substantial number of untested chemicals, a task that requires improved and faster chemical risk assessment strategies that are cost-efficient, human relevant and ethically responsible. In this commentary, we use a case study on five known thyroid toxic chemicals (perfluorooctanesulfonic acid, triclosan, tetrabromobisphenol A, decabromodiphenyl ether and hexabromocyclododecane) to explore the use of in vitro data for hazard assessment together with human biomonitoring (HBM) data for exposure assessment when evaluating human risk. Based on the case study, we conclude that in vitro and HBM data can be used for risk ranking of chemicals. We envision that an in vitro/HBM approach can use data from studies such as the big European initiative Human Biomonitoring for Europe (HBM4EU) together with human-relevant in vitro data to make alternative risk assessment more valuable to finally be able to ‘stand-alone’.",
keywords = "Environmental chemicals, Human biomonitoring, In vitro, PFOS, Risk assessment, Thyroid toxicity",
author = "Johansson, {Hanna Katarina Lilith} and Julie Boberg and Marianne Dybdahl and Marta Axelstad and Vinggaard, {Anne Marie}",
year = "2019",
doi = "10.1016/j.cotox.2018.12.001",
language = "English",
volume = "15",
pages = "8--17",
journal = "Current Opinion in Toxicology",
issn = "2468-2020",
publisher = "Elsevier",

}

TY - JOUR

T1 - Chemical risk assessment based on in vitro and human biomonitoring data: A case study on thyroid toxicants

AU - Johansson, Hanna Katarina Lilith

AU - Boberg, Julie

AU - Dybdahl, Marianne

AU - Axelstad, Marta

AU - Vinggaard, Anne Marie

PY - 2019

Y1 - 2019

N2 - Today, detailed risk assessment can only be performed for a few percent of the total number of current-use chemicals because of lack of data. Toxicity data is, therefore, needed for a substantial number of untested chemicals, a task that requires improved and faster chemical risk assessment strategies that are cost-efficient, human relevant and ethically responsible. In this commentary, we use a case study on five known thyroid toxic chemicals (perfluorooctanesulfonic acid, triclosan, tetrabromobisphenol A, decabromodiphenyl ether and hexabromocyclododecane) to explore the use of in vitro data for hazard assessment together with human biomonitoring (HBM) data for exposure assessment when evaluating human risk. Based on the case study, we conclude that in vitro and HBM data can be used for risk ranking of chemicals. We envision that an in vitro/HBM approach can use data from studies such as the big European initiative Human Biomonitoring for Europe (HBM4EU) together with human-relevant in vitro data to make alternative risk assessment more valuable to finally be able to ‘stand-alone’.

AB - Today, detailed risk assessment can only be performed for a few percent of the total number of current-use chemicals because of lack of data. Toxicity data is, therefore, needed for a substantial number of untested chemicals, a task that requires improved and faster chemical risk assessment strategies that are cost-efficient, human relevant and ethically responsible. In this commentary, we use a case study on five known thyroid toxic chemicals (perfluorooctanesulfonic acid, triclosan, tetrabromobisphenol A, decabromodiphenyl ether and hexabromocyclododecane) to explore the use of in vitro data for hazard assessment together with human biomonitoring (HBM) data for exposure assessment when evaluating human risk. Based on the case study, we conclude that in vitro and HBM data can be used for risk ranking of chemicals. We envision that an in vitro/HBM approach can use data from studies such as the big European initiative Human Biomonitoring for Europe (HBM4EU) together with human-relevant in vitro data to make alternative risk assessment more valuable to finally be able to ‘stand-alone’.

KW - Environmental chemicals

KW - Human biomonitoring

KW - In vitro

KW - PFOS

KW - Risk assessment

KW - Thyroid toxicity

U2 - 10.1016/j.cotox.2018.12.001

DO - 10.1016/j.cotox.2018.12.001

M3 - Journal article

VL - 15

SP - 8

EP - 17

JO - Current Opinion in Toxicology

JF - Current Opinion in Toxicology

SN - 2468-2020

ER -