Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities

Betül Kitir, Alex R. Maolanon, Ragnhild G. Ohm, Ana Rita Freitas Colaço, Peter Fristrup, Andreas S. Madsen, Christian A. Olsen

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Medicine & Life Sciences