TY - JOUR
T1 - Characterization of four new antifungal yanuthones from Aspergillus niger
AU - Petersen, Lene Maj
AU - Holm, Dorte Koefoed
AU - Knudsen, Peter Boldsen
AU - Nielsen, Kristian Fog
AU - Gotfredsen, Charlotte Held
AU - Mortensen, Uffe Hasbro
AU - Larsen, Thomas Ostenfeld
PY - 2015
Y1 - 2015
N2 - Four new yanuthone analogs (1–4) were isolated from the filamentous fungus Aspergillus niger. The structures of the new compounds were elucidated on the basis of UHPLC-DAD-HRMS data and one-dimensional and two-dimensional NMR spectroscopy. Labeling studies with 13C8-6-methylsalicylic acid identified three class I yanuthones originating from the polyketide 6-methylsalicylic acid (yanuthone K, L and M (1–3)) and a class II yanuthone, which was named yanuthone X2 (4). The four new compounds were tested toward the pathogenic yeast Candida albicans and all displayed antifungal activity. Yanuthone X2 represents the first example of a bioactive class II yanuthone, demonstrating the pharmaceutical potential of this class.
AB - Four new yanuthone analogs (1–4) were isolated from the filamentous fungus Aspergillus niger. The structures of the new compounds were elucidated on the basis of UHPLC-DAD-HRMS data and one-dimensional and two-dimensional NMR spectroscopy. Labeling studies with 13C8-6-methylsalicylic acid identified three class I yanuthones originating from the polyketide 6-methylsalicylic acid (yanuthone K, L and M (1–3)) and a class II yanuthone, which was named yanuthone X2 (4). The four new compounds were tested toward the pathogenic yeast Candida albicans and all displayed antifungal activity. Yanuthone X2 represents the first example of a bioactive class II yanuthone, demonstrating the pharmaceutical potential of this class.
U2 - doi:10.1038/ja.2014.130
DO - doi:10.1038/ja.2014.130
M3 - Journal article
SN - 0021-8820
VL - 68
SP - 201
EP - 205
JO - The Journal of Antibiotics
JF - The Journal of Antibiotics
ER -