Characterization of four new antifungal yanuthones from Aspergillus niger

Lene Maj Petersen, Dorte Koefoed Holm, Peter Boldsen Knudsen, Kristian Fog Nielsen, Charlotte Held Gotfredsen, Uffe Hasbro Mortensen, Thomas Ostenfeld Larsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Four new yanuthone analogs (1–4) were isolated from the filamentous fungus Aspergillus niger. The structures of the new compounds were elucidated on the basis of UHPLC-DAD-HRMS data and one-dimensional and two-dimensional NMR spectroscopy. Labeling studies with 13C8-6-methylsalicylic acid identified three class I yanuthones originating from the polyketide 6-methylsalicylic acid (yanuthone K, L and M (1–3)) and a class II yanuthone, which was named yanuthone X2 (4). The four new compounds were tested toward the pathogenic yeast Candida albicans and all displayed antifungal activity. Yanuthone X2 represents the first example of a bioactive class II yanuthone, demonstrating the pharmaceutical potential of this class.
Original languageEnglish
JournalThe Journal of Antibiotics
Volume68
Pages (from-to)201-205
Number of pages5
ISSN0021-8820
DOIs
Publication statusPublished - 2015

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