Chapter 6 – Computer-Aided Molecular Design and Property Prediction

Rafiqul Gani, L. Zhang, Sawitree Kalakul, Stefano Cignitti

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

Today's society needs many chemical-based products for its survival, nutrition, health, transportation, agriculture, and the functioning of processes. Chemical-based products have to be designed/developed in order to meet these needs, while at the same time, they must be innovative and sustainable to meet the global challenges of resources, competition, and demand. Design/development of these products mostly follows experiment-based trial and error approaches. With the availability of reliable property prediction models, however, computer-aided techniques have become popular, at least for the initial stages of the design/development process. Therefore, computer-aided molecular design and property prediction techniques are two topics that play important roles in chemical product design, analysis, and application. In this chapter, an overview of the concepts, methods, and tools related to these two topics are given. In addition, a generic computer-aided framework for the design of molecules, mixtures, and blends is presented. The application of the framework is highlighted for molecular products through two case studies involving the design of refrigerants and surfactants.
Original languageEnglish
Title of host publicationComputer Aided Chemical Engineering : Tools For Chemical Product Design — From Consumer Products to Biomedicine
EditorsMariano Martín, Mario R. Eden , Nishanth G. Chemmangattuvalappil
Volume39
PublisherElsevier
Publication date2017
Pages153–196
Chapter6
ISBN (Print)978-0-444-63683-6
DOIs
Publication statusPublished - 2017
SeriesComputer Aided Chemical Engineering
Volume39
ISSN1570-7946

Keywords

  • Computer-aided molecular design (CAMD)
  • Framework
  • Lubricant
  • Mathematical programming
  • Molecular design
  • Property prediction
  • Refrigerant

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