Changes in the left temporal microstate are a sign of cognitive decline in patients with Alzheimer's disease

Christian S Musaeus, Knut Engedal, Peter Høgh, Vesna Jelic, Arjun R Khanna, Troels Wesenberg Kjaer, Morten Mørup, Mala Naik, Anne-Rita Oeksengaard, Emiliano Santarnecchi, Jon Snaedal, Lars-Olof Wahlund, Gunhild Waldemar, Birgitte B Andersen

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Abstract

Large-scale brain networks are disrupted in the early stages of Alzheimer's disease (AD). Electroencephalography microstate analysis, a promising method for studying brain networks, parses EEG signals into topographies representing discrete, sequential network activations. Prior studies indicate that patients with AD show a pattern of global microstate disorganization. We investigated whether any specific microstate changes could be found in patients with AD and mild cognitive impairment (MCI) compared to healthy controls (HC). Standard EEGs were obtained from 135 HC, 117 patients with MCI, and 117 patients with AD from six Nordic memory clinics. We parsed the data into four archetypal microstates. There was significantly increased duration, occurrence, and coverage of microstate A in patients with AD and MCI compared to HC. When looking at microstates in specific frequency bands, we found that microstate A was affected in delta (1-4 Hz), theta (4-8 Hz), and beta (13-30 Hz), while microstate D was affected only in the delta and theta bands. Microstate features were able to separate HC from AD with an accuracy of 69.8% and HC from MCI with an accuracy of 58.7%. Further studies are needed to evaluate whether microstates represent a valuable disease classifier. Overall, patients with AD and MCI, as compared to HC, show specific microstate alterations, which are limited to specific frequency bands. These alterations suggest disruption of large-scale cortical networks in AD and MCI, which may be limited to specific frequency bands.
Original languageEnglish
Article numbere01630
JournalBrain and Behavior
Volume10
Issue number6
Number of pages15
ISSN2162-3279
DOIs
Publication statusPublished - 2020

Keywords

  • Alzheimer's disease
  • EEG
  • Microstate
  • Mild cognitive impairment
  • Network

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