TY - JOUR
T1 - Certain dietary carbohydrates promote Listeria infection in a guinea pig model, while others prevent it
AU - Ebersbach, Tine
AU - Jørgensen, Julie Boeck
AU - Heegaard, Peter M. H.
AU - Lahtinen, Sampo J.
AU - Ouwehand, Arthur C.
AU - Poulsen, Morten
AU - Frokiær, Hanne
AU - Licht, Tine Rask
PY - 2010
Y1 - 2010
N2 - It has been proposed that dietary non-digestible carbohydrates can improve host resistance to intestinal infections by stimulating health-promoting bacteria in the gut. However, evidence from in vivo infection studies is scarce, particularly for gram-positive infections. We studied the effect of five non-digestible carbohydrates on the resistance of guinea pigs to Listeria monocytogenes infections. Animals were fed a diet supplemented with 10% xylooligosaccharides (XOS), galactooligosaccharides (GOS), inulin, apple pectin or polydextrose for three weeks before oral infection with a mixture of three different fluorescently labeled L monocytogenes strains. Colonisation of L. monocytogenes in the intestine was determined by quantification of L. monocytogenes in faecal, ileal and caecal samples while translocation was determined by quantification of L monocytogenes in mesenteric lymph nodes, spleen and liver. XOS and GOS significantly (P
AB - It has been proposed that dietary non-digestible carbohydrates can improve host resistance to intestinal infections by stimulating health-promoting bacteria in the gut. However, evidence from in vivo infection studies is scarce, particularly for gram-positive infections. We studied the effect of five non-digestible carbohydrates on the resistance of guinea pigs to Listeria monocytogenes infections. Animals were fed a diet supplemented with 10% xylooligosaccharides (XOS), galactooligosaccharides (GOS), inulin, apple pectin or polydextrose for three weeks before oral infection with a mixture of three different fluorescently labeled L monocytogenes strains. Colonisation of L. monocytogenes in the intestine was determined by quantification of L. monocytogenes in faecal, ileal and caecal samples while translocation was determined by quantification of L monocytogenes in mesenteric lymph nodes, spleen and liver. XOS and GOS significantly (P
U2 - 10.1016/j.ijfoodmicro.2010.03.030
DO - 10.1016/j.ijfoodmicro.2010.03.030
M3 - Journal article
C2 - 20417983
SN - 0168-1605
VL - 140
SP - 218
EP - 224
JO - International Journal of Food Microbiology
JF - International Journal of Food Microbiology
IS - 2-3
ER -