Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study

Morten Blinkenberg; Henrik K Mathiesen; Thomas Tscherning; Agnete Jønsson; Claus Svarer; Søren Holm; Finn Sellebjerg; Olaf B Paulson; Lars G. Hanson; Per S Sorensen

doi:10.1179/1743132811Y.0000000059

Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study

Morten Blinkenberg, Henrik K Mathiesen, Thomas Tscherning, Agnete Jønsson, Claus Svarer, Søren Holm, Finn Sellebjerg, Olaf B Paulson, Lars G. Hanson, Per S Sorensen

Copenhagen University Hospital Herlev and Gentofte

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

OBJECTIVES: Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability. METHODS: We studied 20 recently diagnosed, clinically definite, relapsing-remitting MS patients. Global and cortical CMRglc was estimated using PET with 18-F-deoxyglucose and NAA/Cr ratio was measured using multislice echo-planar spectroscopic imaging. All subjects were neuro-psychologically tested and a cognitive dysfunction factor (CDF) was calculated. RESULTS: Cortical CMRglc correlated with cortical NAA/Cr (r = 0·45; P

Original language	English
Journal	Neurological Research
Volume	34
Issue number	1
Pages (from-to)	52-58
ISSN	0161-6412
DOIs	https://doi.org/10.1179/1743132811Y.0000000059
Publication status	Published - 2012

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Blinkenberg, M., Mathiesen, H. K., Tscherning, T., Jønsson, A., Svarer, C., Holm, S., Sellebjerg, F., Paulson, O. B., Hanson, L. G., & Sorensen, P. S. (2012). Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study. Neurological Research, 34(1), 52-58. https://doi.org/10.1179/1743132811Y.0000000059

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title = "Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study",

abstract = "OBJECTIVES: Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability. METHODS: We studied 20 recently diagnosed, clinically definite, relapsing-remitting MS patients. Global and cortical CMRglc was estimated using PET with 18-F-deoxyglucose and NAA/Cr ratio was measured using multislice echo-planar spectroscopic imaging. All subjects were neuro-psychologically tested and a cognitive dysfunction factor (CDF) was calculated. RESULTS: Cortical CMRglc correlated with cortical NAA/Cr (r = 0·45; P",

author = "Morten Blinkenberg and Mathiesen, {Henrik K} and Thomas Tscherning and Agnete J{\o}nsson and Claus Svarer and S{\o}ren Holm and Finn Sellebjerg and Paulson, {Olaf B} and Hanson, {Lars G.} and Sorensen, {Per S}",

year = "2012",

doi = "10.1179/1743132811Y.0000000059",

language = "English",

volume = "34",

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T1 - Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study

AU - Blinkenberg, Morten

AU - Mathiesen, Henrik K

AU - Tscherning, Thomas

AU - Jønsson, Agnete

AU - Svarer, Claus

AU - Holm, Søren

AU - Sellebjerg, Finn

AU - Paulson, Olaf B

AU - Hanson, Lars G.

AU - Sorensen, Per S

PY - 2012

Y1 - 2012

N2 - OBJECTIVES: Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability. METHODS: We studied 20 recently diagnosed, clinically definite, relapsing-remitting MS patients. Global and cortical CMRglc was estimated using PET with 18-F-deoxyglucose and NAA/Cr ratio was measured using multislice echo-planar spectroscopic imaging. All subjects were neuro-psychologically tested and a cognitive dysfunction factor (CDF) was calculated. RESULTS: Cortical CMRglc correlated with cortical NAA/Cr (r = 0·45; P

AB - OBJECTIVES: Positron emission tomography (PET) studies have shown that cortical cerebral metabolic rate of glucose (CMRglc) is reduced in multiple sclerosis (MS). Quantitative magnetic resonance spectroscopy (MRS) measures of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) assess neuronal deterioration, and several studies have shown reductions in MS. Furthermore, both PET and MRS reductions correlate with cognitive dysfunction in MS. Our aim was to determine if changes in cortical CMRglc in early MS correlate with NAA/Cr measurements of neuronal deterioration, as well as cognitive dysfunction and neurological disability. METHODS: We studied 20 recently diagnosed, clinically definite, relapsing-remitting MS patients. Global and cortical CMRglc was estimated using PET with 18-F-deoxyglucose and NAA/Cr ratio was measured using multislice echo-planar spectroscopic imaging. All subjects were neuro-psychologically tested and a cognitive dysfunction factor (CDF) was calculated. RESULTS: Cortical CMRglc correlated with cortical NAA/Cr (r = 0·45; P

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DO - 10.1179/1743132811Y.0000000059

M3 - Journal article

C2 - 22196862

VL - 34

SP - 52

EP - 58

JO - Neurological Research

JF - Neurological Research

SN - 0161-6412

IS - 1

ER -

Cerebral metabolism, magnetic resonance spectroscopy and cognitive dysfunction in early multiple sclerosis: an exploratory study

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