Cerebral 5-HT2A receptor binding is increased in patients with Tourette's syndrome

Steven Haugbøl, Lars H. Pinborg, Lisbeth Regeur, Elsebet S. Hansen, Tom G. Bolwig, Finn Årup Nielsen, Claus Svarer, Lene T. Skovgaard, Gitte Moos Knudsen

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    Experimental and clinical data have suggested that abnormalities in the serotonergic neurotransmissions in frontal-subcortical circuits are involved in Tourette's syndrome. To test the hypothesis that the brain's 5-HT2A receptor binding is increased in patients with Tourette's syndrome, PET imaging was performed. Twenty adults with Tourette's syndrome and 20 healthy control subjects were investigated with PET-[18F]altanserin using a bolus-infusion protocol. Regions of interest were delineated automatically on co-registered MRI images, and partial volume-corrected binding parameters were extracted from the PET images. Comparison between control subjects and Tourette's syndrome patients showed increased specific [18F]altanserin binding, not only in the a-priori selected brain regions hypothesized to be involved in Tourette's syndrome, but also post-hoc analysis showed a global up-regulation when testing for a overall difference with a randomization test (p
    Original languageEnglish
    JournalThe International Journal of Neuropsychopharmacology
    Volume10
    Issue number2
    Pages (from-to)245-252
    ISSN1461-1457
    DOIs
    Publication statusPublished - 2007

    Keywords

    • serotonin
    • Positron emission tomography
    • brain
    • human

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