Ceramides and barrier function in healthy skin

J Jungerstedt, Lars Hellgren, Tue Drachmann, Julie Kaae Høgh, GBE Jemec, T Agner

    Research output: Contribution to journalJournal articlepeer-review

    825 Downloads (Pure)

    Abstract

    Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02).
    Original languageEnglish
    JournalActa Dermatovenereologica
    Volume90
    Issue number4
    Pages (from-to)350-353
    ISSN0001-5555
    DOIs
    Publication statusPublished - 2010

    Keywords

    • ceramides
    • age
    • gender
    • ceramide/cholesterol ratio
    • TEWL
    • stratum corneum

    Fingerprint

    Dive into the research topics of 'Ceramides and barrier function in healthy skin'. Together they form a unique fingerprint.

    Cite this