Cell-laden alginate hydrogels for the treatment of diabetes

Lukin Izeia, Tatiane Eufrásio da Silva, Alireza Dolatshahi-Pirouz, Serge Ostrovidov, Giovanna Paolone, Nicholas A. Peppas, Paul De Vos, Dwaine Emerich, Gorka Orive*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

Introduction: Diabetes mellitus is an ever-increasing medical condition that currently suffers 1 of 11 adults who may have lifelong commitment with insulin injections. Cell-laden hydrogels releasing insulin may provide the ultimate means of correcting diabetes. Here, we provide insights of this cell-based approach including latest preclinical and clinical progress both from academia and industry.
Area covered: The present article focuses on reviewing latest advances in cell-laden hydrogels both from the technological and biological perspective. The most relevant clinical results including clinical trials are also discussed.
Expert opinion: Current progress in technological issues (stem cells, devices, biomaterials) have contributed cell encapsulation science to have a very relevant progress in the field of diabetes treatment.
Original languageEnglish
JournalExpert Opinion on Drug Delivery
Volume17
Issue number8
Pages (from-to)1113-1118
ISSN1742-5247
DOIs
Publication statusPublished - 2020

Keywords

  • Diabetes mellitus
  • Cell encapsulation
  • Cell-laden hydrogels
  • Alginate
  • Drug delivery

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