Cell factories for industrial production processes: Current issues and emerging solutions

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Despite all the progresses made by metabolic engineering, still only a few biotechnological processes are running at an industrial level. In order to boost the biotechnological sector, integration strategies as well as long-term views are needed. The aim of the present review is to identify the main drawbacks in biotechnological processes, and to propose possible solutions to overcome the issues in question. Novel cell factories and bioreactor design are discussed as possible solutions. In particular, the following microorganisms: Yarrowia lipolytica, Trichosporon oleaginosus, Ustilago cynodontis, Debaryomyces hansenii along with sequential bioreactor configurations are presented as possible cell factories and bioreactor design solutions, respectively.
Original languageEnglish
Article number768
Issue number7
Number of pages19
Publication statusPublished - 2020


  • Cell factory
  • Lignocellulosic biomass
  • Biomass pretreatment
  • Lignocellulosic inhibitors
  • Yarrowia lipolytica
  • Trichosporon oleaginosus
  • Ustilago cynodontis
  • Debraryomyces hansenii
  • Bioreactor configuration

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