Cell factories for industrial production processes: Current issues and emerging solutions

Clara Navarrete; Irene Hjorth Jacobsen; José Luis Martínez; Alessandra Procentese

doi:10.3390/pr8070768

Cell factories for industrial production processes: Current issues and emerging solutions

Clara Navarrete, Irene Hjorth Jacobsen, José Luis Martínez, Alessandra Procentese^*

^*Corresponding author for this work

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Abstract

Despite all the progresses made by metabolic engineering, still only a few biotechnological processes are running at an industrial level. In order to boost the biotechnological sector, integration strategies as well as long-term views are needed. The aim of the present review is to identify the main drawbacks in biotechnological processes, and to propose possible solutions to overcome the issues in question. Novel cell factories and bioreactor design are discussed as possible solutions. In particular, the following microorganisms: Yarrowia lipolytica, Trichosporon oleaginosus, Ustilago cynodontis, Debaryomyces hansenii along with sequential bioreactor configurations are presented as possible cell factories and bioreactor design solutions, respectively.

Original language	English
Article number	768
Journal	Processes
Volume	8
Issue number	7
Number of pages	19
ISSN	2227-9717
DOIs	https://doi.org/10.3390/pr8070768
Publication status	Published - 2020

Keywords

Cell factory
Lignocellulosic biomass
Biomass pretreatment
Lignocellulosic inhibitors
Yarrowia lipolytica
Trichosporon oleaginosus
Ustilago cynodontis
Debraryomyces hansenii
Bioreactor configuration

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abstract = "Despite all the progresses made by metabolic engineering, still only a few biotechnological processes are running at an industrial level. In order to boost the biotechnological sector, integration strategies as well as long-term views are needed. The aim of the present review is to identify the main drawbacks in biotechnological processes, and to propose possible solutions to overcome the issues in question. Novel cell factories and bioreactor design are discussed as possible solutions. In particular, the following microorganisms: Yarrowia lipolytica, Trichosporon oleaginosus, Ustilago cynodontis, Debaryomyces hansenii along with sequential bioreactor configurations are presented as possible cell factories and bioreactor design solutions, respectively.",

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author = "Clara Navarrete and Jacobsen, {Irene Hjorth} and Mart{\'i}nez, {Jos{\'e} Luis} and Alessandra Procentese",

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AU - Navarrete, Clara

AU - Jacobsen, Irene Hjorth

AU - Martínez, José Luis

AU - Procentese, Alessandra

PY - 2020

Y1 - 2020

N2 - Despite all the progresses made by metabolic engineering, still only a few biotechnological processes are running at an industrial level. In order to boost the biotechnological sector, integration strategies as well as long-term views are needed. The aim of the present review is to identify the main drawbacks in biotechnological processes, and to propose possible solutions to overcome the issues in question. Novel cell factories and bioreactor design are discussed as possible solutions. In particular, the following microorganisms: Yarrowia lipolytica, Trichosporon oleaginosus, Ustilago cynodontis, Debaryomyces hansenii along with sequential bioreactor configurations are presented as possible cell factories and bioreactor design solutions, respectively.

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KW - Lignocellulosic biomass

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KW - Lignocellulosic inhibitors

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KW - Trichosporon oleaginosus

KW - Ustilago cynodontis

KW - Debraryomyces hansenii

KW - Bioreactor configuration

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Cell factories for industrial production processes: Current issues and emerging solutions

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Keywords

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