CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin

Research output: Contribution to journalJournal article – Annual report year: 2017Researchpeer-review

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  • Author: Cheuk, Stanley

    Karolinska Institutet, Sweden

  • Author: Schlums, Heinrich

    Karolinska Institutet, Sweden

  • Author: Sérézal, Irène Gallais

    Karolinska Institutet, Sweden

  • Author: Martini, Elisa

    Karolinska Institutet, Sweden

  • Author: Chiang, Samuel C.

    Karolinska Institutet, Sweden

  • Author: Marquardt, Nicole

    Karolinska University Hospital, Sweden

  • Author: Gibbs, Anna

    Karolinska Institutet, Sweden

  • Author: Detlofsson, Ebba

    Karolinska Institutet, Sweden

  • Author: Introini, Andrea

    Karolinska Institutet, Sweden

  • Author: Forkel, Marianne

    Karolinska University Hospital, Sweden

  • Author: Höög, Charlotte

    Karolinska Institutet, Sweden

  • Author: Tjernlund, Annelie

    Karolinska Institutet, Sweden

  • Author: Michaelsson, Jakob

    Karolinska University Hospital

  • Author: Folkersen, Lasse Westergaard

    Integrative Systems Biology, Department of Bio and Health Informatics, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Mjösberg, Jenny

    Karolinska University Hospital, Sweden

  • Author: Blomqvist, Lennart

    Karolinska Institutet, Sweden

  • Author: Ehrström, Marcus

    Karolinska University Hospital, Sweden

  • Author: Ståhle, Mona

    Karolinska Institutet, Sweden

  • Author: Bryceson, Yenan T.

    Karolinska Institutet, Sweden

  • Author: Eidsmo, Liv

    Karolinska Institutet, Sweden

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Tissue-resident memory T (Trm) cells form a heterogeneous population that provides localized protection against pathogens. Here, we identify CD49a as a marker that differentiates CD8+ Trm cells on a compartmental and functional basis. In human skin epithelia, CD8+CD49a+ Trm cells produced interferon-γ, whereas CD8+CD49a− Trm cells produced interleukin-17 (IL-17). In addition, CD8+CD49a+ Trm cells from healthy skin rapidly induced the expression of the effector molecules perforin and granzyme B when stimulated with IL-15, thereby promoting a strong cytotoxic response. In skin from patients with vitiligo, where melanocytes are eradicated locally, CD8+CD49a+ Trm cells that constitutively expressed perforin and granzyme B accumulated both in the epidermis and dermis. Conversely, CD8+CD49a– Trm cells from psoriasis lesions predominantly generated IL-17 responses that promote local inflammation in this skin disease. Overall, CD49a expression delineates CD8+ Trm cell specialization in human epithelial barriers and correlates with the effector cell balance found in distinct inflammatory skin diseases.
Original languageEnglish
JournalImmunity
Volume46
Issue number2
Pages (from-to)287-300
ISSN1074-7613
DOIs
Publication statusPublished - 2017

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Open Access funded by European Research Council
Under a Creative Commons license

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