Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells

Faina Karchemski; Daniel Zucker; Yechezkel Barenholz; Oren Regev

doi:10.1016/j.jconrel.2011.12.037

Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells

Faina Karchemski, Daniel Zucker, Yechezkel Barenholz, Oren Regev

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a newdrug delivery system, inwhich drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlledmeans for enhanced delivery of one ormore agents stably associated with the liposomes.
Keyword: Drug delivery,Carbon-nanotubes,Liposome,Cell viability,TEM (transmission electron microscopy)

Original language	English
Journal	Journal of Controlled Release
ISSN	0168-3659
DOIs	https://doi.org/10.1016/j.jconrel.2011.12.037
Publication status	Published - 2012
Externally published	Yes

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title = "Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells",

abstract = "Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a newdrug delivery system, inwhich drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlledmeans for enhanced delivery of one ormore agents stably associated with the liposomes. Keyword: Drug delivery,Carbon-nanotubes,Liposome,Cell viability,TEM (transmission electron microscopy)",

author = "Faina Karchemski and Daniel Zucker and Yechezkel Barenholz and Oren Regev",

year = "2012",

doi = "10.1016/j.jconrel.2011.12.037",

language = "English",

journal = "Journal of Controlled Release",

issn = "0168-3659",

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TY - JOUR

T1 - Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells

AU - Karchemski, Faina

AU - Zucker, Daniel

AU - Barenholz, Yechezkel

AU - Regev, Oren

PY - 2012

Y1 - 2012

N2 - Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a newdrug delivery system, inwhich drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlledmeans for enhanced delivery of one ormore agents stably associated with the liposomes. Keyword: Drug delivery,Carbon-nanotubes,Liposome,Cell viability,TEM (transmission electron microscopy)

AB - Carbon nanotubes (CNT) are widely explored as carriers for drug delivery due to their facile transport through cellular membranes. However, the amount of loaded drug on a CNT is rather small. Liposomes, on the other hand, are employed as a carrier of a large amount of drug. The aim of this research is to develop a newdrug delivery system, inwhich drug-loaded liposomes are covalently attached to CNT to form a CNT-liposomes conjugate (CLC). The advantage of this novel approach is the large amount of drug that can be delivered into cells by the CLC system, thus preventing potential adverse systemic effects of CNT when administered at high doses. This system is expected to provide versatile and controlledmeans for enhanced delivery of one ormore agents stably associated with the liposomes. Keyword: Drug delivery,Carbon-nanotubes,Liposome,Cell viability,TEM (transmission electron microscopy)

U2 - 10.1016/j.jconrel.2011.12.037

DO - 10.1016/j.jconrel.2011.12.037

M3 - Journal article

C2 - 22245689

SN - 0168-3659

JO - Journal of Controlled Release

JF - Journal of Controlled Release

ER -

Carbon nanotubes-liposomes conjugate as a platform for drug delivery into cells

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