Capsule shields the function of short bacterial adhesins

Mark Schembri, D. Dalsgaard, Per Klemm

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Bacterial surface structures such as capsules and adhesins are generally regarded as important virulence factors. Here we demonstrate that capsules block the function of the self-recognizing protein antigen 43 through physical shielding. The phenomenon is not restricted to Escherichia coli but can occur in other gram-negative bacteria. Likewise, we show that other short adhesins exemplified by the AIDA-I protein are blocked by the presence of a capsule. The results support the notion that capsule polysaccharides sterically prevent receptor-target recognition of short bacterial adhesins. This negative interference has important biological consequences, such as affecting the ability of bacteria to form biofilms.
    Original languageEnglish
    JournalJournal of Bacteriology
    Volume186
    Pages (from-to)1249-1257
    ISSN0021-9193
    Publication statusPublished - 2004

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