Cantilever biosensor reader using a common-path, holographic optical interferometer

Henrik Chresten Pedersen; Michael Linde Jakobsen; Steen Grüner Hanson; Carsten Dam-Hansen; Tom Olesen; Poul Hansen

doi:10.1063/1.3522888

Cantilever biosensor reader using a common-path, holographic optical interferometer

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Abstract

We demonstrate an optical reader principle aimed at monitoring biologically induced deflections of microcantilevers often used in biosensor systems. The principle is based on a so-called common-path optical interferometer in which the two interfering optical beams are copropagating,which makes the system less sensitive to external disturbances. A detection limit of around 1 nm’s deflection is demonstrated.

Original language	English
Journal	Applied Physics Letters
Volume	97
Issue number	22
Pages (from-to)	221110
ISSN	0003-6951
DOIs	https://doi.org/10.1063/1.3522888
Publication status	Published - 2010

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Copyright (2010) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

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title = "Cantilever biosensor reader using a common-path, holographic optical interferometer",

abstract = "We demonstrate an optical reader principle aimed at monitoring biologically induced deflections of microcantilevers often used in biosensor systems. The principle is based on a so-called common-path optical interferometer in which the two interfering optical beams are copropagating,which makes the system less sensitive to external disturbances. A detection limit of around 1 nm{\textquoteright}s deflection is demonstrated.",

author = "Pedersen, \{Henrik Chresten\} and Jakobsen, \{Michael Linde\} and Hanson, \{Steen Gr{\"u}ner\} and Carsten Dam-Hansen and Tom Olesen and Poul Hansen",

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T1 - Cantilever biosensor reader using a common-path, holographic optical interferometer

AU - Pedersen, Henrik Chresten

AU - Jakobsen, Michael Linde

AU - Hanson, Steen Grüner

AU - Dam-Hansen, Carsten

AU - Olesen, Tom

AU - Hansen, Poul

N1 - Copyright (2010) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

PY - 2010

Y1 - 2010

N2 - We demonstrate an optical reader principle aimed at monitoring biologically induced deflections of microcantilevers often used in biosensor systems. The principle is based on a so-called common-path optical interferometer in which the two interfering optical beams are copropagating,which makes the system less sensitive to external disturbances. A detection limit of around 1 nm’s deflection is demonstrated.

AB - We demonstrate an optical reader principle aimed at monitoring biologically induced deflections of microcantilevers often used in biosensor systems. The principle is based on a so-called common-path optical interferometer in which the two interfering optical beams are copropagating,which makes the system less sensitive to external disturbances. A detection limit of around 1 nm’s deflection is demonstrated.

U2 - 10.1063/1.3522888

DO - 10.1063/1.3522888

M3 - Journal article

SN - 0003-6951

VL - 97

SP - 221110

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 22

ER -

Cantilever biosensor reader using a common-path, holographic optical interferometer

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