Cantilever biosensor reader using a common-path, holographic optical interferometer

Henrik Chresten Pedersen; Michael Linde Jakobsen; Steen Grüner Hanson; Carsten Dam-Hansen; Tom Olesen; Poul Hansen

doi:10.1063/1.3522888

Cantilever biosensor reader using a common-path, holographic optical interferometer

Henrik Chresten Pedersen, Michael Linde Jakobsen, Steen Grüner Hanson, Carsten Dam-Hansen, Tom Olesen, Poul Hansen

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Abstract

We demonstrate an optical reader principle aimed at monitoring biologically induced deflections of microcantilevers often used in biosensor systems. The principle is based on a so-called common-path optical interferometer in which the two interfering optical beams are copropagating,which makes the system less sensitive to external disturbances. A detection limit of around 1 nm’s deflection is demonstrated.

Original language	English
Journal	Applied Physics Letters
Volume	97
Issue number	22
Pages (from-to)	221110
ISSN	0003-6951
DOIs	https://doi.org/10.1063/1.3522888
Publication status	Published - 2010

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Copyright (2010) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

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10.1063/1.3522888

Cantilever biosensor reader using a common-pathFinal published version, 2.05 MB

http://link.aip.org/link/?APL/97/221110

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AU - Pedersen, Henrik Chresten

AU - Jakobsen, Michael Linde

AU - Hanson, Steen Grüner

AU - Dam-Hansen, Carsten

AU - Olesen, Tom

AU - Hansen, Poul

N1 - Copyright (2010) American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.

PY - 2010

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N2 - We demonstrate an optical reader principle aimed at monitoring biologically induced deflections of microcantilevers often used in biosensor systems. The principle is based on a so-called common-path optical interferometer in which the two interfering optical beams are copropagating,which makes the system less sensitive to external disturbances. A detection limit of around 1 nm’s deflection is demonstrated.

AB - We demonstrate an optical reader principle aimed at monitoring biologically induced deflections of microcantilevers often used in biosensor systems. The principle is based on a so-called common-path optical interferometer in which the two interfering optical beams are copropagating,which makes the system less sensitive to external disturbances. A detection limit of around 1 nm’s deflection is demonstrated.

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M3 - Journal article

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SP - 221110

JO - Applied Physics Letters

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Cantilever biosensor reader using a common-path, holographic optical interferometer

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