Cantilever-based micro-particle filter with simultaneous single particle detection

Nadine-Nicole Noeth, Stephan Sylvest Keller, Anja Boisen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Currently, separation of whole blood samples on lab-on-a-chip systems is achieved via filters followed by analysis of the filtered matter such as counting of blood cells. Here, a micro-chip based on cantilever technology is developed, which enables simultaneous filtration and counting of micro-particles from a liquid. A hole-array is integrated into a micro-cantilever, which is inserted into a microfluidic channel perpendicular to the flow. A metal pad at the apex of the cantilever enables an optical read-out of the deflection of the cantilever. When a micro-particle is too large to pass a hole in the cantilever, clogging of the holes increases the flow resistance of the cantilever. This causes a bending of the device, which can be detected by the optical read-out system. By arranging an array of such cantilevers with different hole sizes, separation by size can be achieved. In this paper a proof of concept of the device is demonstrated by filtering and counting 20 mu m polystyrene beads dispersed in an aqueous solution.
    Original languageEnglish
    JournalJournal of Micromechanics and Microengineering
    Volume21
    Issue number5
    ISSN0960-1317
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Filters
    • Physiological materials (e.g. blood, collagen, etc.)
    • Fluidics
    • Tissue engineering
    • Flow phenomena in quasi-one-dimensional systems

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