Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET

Anders Nymark Christensen, Michala H. Reichkendler, Rasmus Larsen, Pernille Auerbach, Liselotte Højgaard, Henning B. Nielsen, Thorkil Ploug, Bente Stallknecht, Søren Holm

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We investigated the use of a simple calibration method to remove bias in previously proposed approaches to image-derived input functions (IDIFs) when used to calculate the metabolic uptake rate of glucose (Km) from dynamic [18F]-FDG PET scans of the thigh. Our objective was to obtain nonbiased, low-variance Km values without blood sampling.
Original languageEnglish
JournalNuclear Medicine Communications
Volume35
Issue number4
Pages (from-to)353-361
ISSN0143-3636
DOIs
Publication statusPublished - 2014

Keywords

  • calibration
  • image-derived input function
  • kinetic analysis
  • positron emission tomography

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