Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET

Anders Nymark Christensen; Michala H. Reichkendler; Rasmus Larsen; Pernille Auerbach; Liselotte Højgaard; Henning B. Nielsen; Thorkil Ploug; Bente Stallknecht; Søren Holm

doi:1097/MNM.0000000000000063

Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET

Anders Nymark Christensen, Michala H. Reichkendler, Rasmus Larsen, Pernille Auerbach, Liselotte Højgaard, Henning B. Nielsen, Thorkil Ploug, Bente Stallknecht, Søren Holm

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We investigated the use of a simple calibration method to remove bias in previously proposed approaches to image-derived input functions (IDIFs) when used to calculate the metabolic uptake rate of glucose (K_m) from dynamic [¹⁸F]-FDG PET scans of the thigh. Our objective was to obtain nonbiased, low-variance K_m values without blood sampling.

Original language	English
Journal	Nuclear Medicine Communications
Volume	35
Issue number	4
Pages (from-to)	353-361
ISSN	0143-3636
DOIs	https://doi.org/1097/MNM.0000000000000063
Publication status	Published - 2014

Keywords

calibration
image-derived input function
kinetic analysis
positron emission tomography

Access to Document

1097/MNM.0000000000000063

OpenUrl availability

Full text

Cite this

@article{ba225c43c46c4f7ba87b52acd666547d,

title = "Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET",

abstract = "We investigated the use of a simple calibration method to remove bias in previously proposed approaches to image-derived input functions (IDIFs) when used to calculate the metabolic uptake rate of glucose (Km) from dynamic [18F]-FDG PET scans of the thigh. Our objective was to obtain nonbiased, low-variance Km values without blood sampling.",

keywords = "calibration, image-derived input function, kinetic analysis, positron emission tomography",

author = "Christensen, {Anders Nymark} and Reichkendler, {Michala H.} and Rasmus Larsen and Pernille Auerbach and Liselotte H{\o}jgaard and Nielsen, {Henning B.} and Thorkil Ploug and Bente Stallknecht and S{\o}ren Holm",

year = "2014",

doi = "1097/MNM.0000000000000063",

language = "English",

volume = "35",

pages = "353--361",

journal = "Nuclear Medicine Communications",

issn = "0143-3636",

publisher = "Lippincott Williams & Wilkins",

number = "4",

}

TY - JOUR

T1 - Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET

AU - Christensen, Anders Nymark

AU - Reichkendler, Michala H.

AU - Larsen, Rasmus

AU - Auerbach, Pernille

AU - Højgaard, Liselotte

AU - Nielsen, Henning B.

AU - Ploug, Thorkil

AU - Stallknecht, Bente

AU - Holm, Søren

PY - 2014

Y1 - 2014

N2 - We investigated the use of a simple calibration method to remove bias in previously proposed approaches to image-derived input functions (IDIFs) when used to calculate the metabolic uptake rate of glucose (Km) from dynamic [18F]-FDG PET scans of the thigh. Our objective was to obtain nonbiased, low-variance Km values without blood sampling.

AB - We investigated the use of a simple calibration method to remove bias in previously proposed approaches to image-derived input functions (IDIFs) when used to calculate the metabolic uptake rate of glucose (Km) from dynamic [18F]-FDG PET scans of the thigh. Our objective was to obtain nonbiased, low-variance Km values without blood sampling.

KW - calibration

KW - image-derived input function

KW - kinetic analysis

KW - positron emission tomography

U2 - 1097/MNM.0000000000000063

DO - 1097/MNM.0000000000000063

M3 - Journal article

SN - 0143-3636

VL - 35

SP - 353

EP - 361

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

IS - 4

ER -

Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET

Abstract

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this