Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils

Pasquale Sacco, Eva Decleva, Fabio Tentor, Renzo Menegazzi, Massimiliano Borgogna, Sergio Paoletti, Kåre Andre Kristiansen, Kjell Morten Vårum, Eleonora Marsich

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    Abstract

    Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion. Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA. Notably, while the inhibition of neutrophil ROS production by free butyrate declines over time, that of butyrate-loaded chitosan/hyaluronan nanoparticles (B-NPs) is sustained. Additional valuable features of these nanoparticles are inherent ROS scavenger activity, resistance to cell internalization, and mucoadhesiveness. B-NPs appear as promising tools to limit ROS-dependent tissue injury during inflammation. Particularly, by virtue of their mucoadhesiveness, B-NPs administered by enema can be effective in the treatment of inflammatory bowel diseases.
    Original languageEnglish
    Article number1700214
    JournalMacromolecular Bioscience
    Volume17
    Issue number11
    Number of pages13
    ISSN1616-5187
    DOIs
    Publication statusPublished - 2017

    Cite this

    Sacco, Pasquale ; Decleva, Eva ; Tentor, Fabio ; Menegazzi, Renzo ; Borgogna, Massimiliano ; Paoletti, Sergio ; Kristiansen, Kåre Andre ; Vårum, Kjell Morten ; Marsich, Eleonora. / Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils. In: Macromolecular Bioscience. 2017 ; Vol. 17, No. 11.
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    title = "Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils",
    abstract = "Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion. Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA. Notably, while the inhibition of neutrophil ROS production by free butyrate declines over time, that of butyrate-loaded chitosan/hyaluronan nanoparticles (B-NPs) is sustained. Additional valuable features of these nanoparticles are inherent ROS scavenger activity, resistance to cell internalization, and mucoadhesiveness. B-NPs appear as promising tools to limit ROS-dependent tissue injury during inflammation. Particularly, by virtue of their mucoadhesiveness, B-NPs administered by enema can be effective in the treatment of inflammatory bowel diseases.",
    author = "Pasquale Sacco and Eva Decleva and Fabio Tentor and Renzo Menegazzi and Massimiliano Borgogna and Sergio Paoletti and Kristiansen, {K{\aa}re Andre} and V{\aa}rum, {Kjell Morten} and Eleonora Marsich",
    year = "2017",
    doi = "10.1002/mabi.201700214",
    language = "English",
    volume = "17",
    journal = "Macromolecular Bioscience",
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    Sacco, P, Decleva, E, Tentor, F, Menegazzi, R, Borgogna, M, Paoletti, S, Kristiansen, KA, Vårum, KM & Marsich, E 2017, 'Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils', Macromolecular Bioscience, vol. 17, no. 11, 1700214. https://doi.org/10.1002/mabi.201700214

    Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils. / Sacco, Pasquale; Decleva, Eva; Tentor, Fabio; Menegazzi, Renzo; Borgogna, Massimiliano; Paoletti, Sergio; Kristiansen, Kåre Andre; Vårum, Kjell Morten; Marsich, Eleonora.

    In: Macromolecular Bioscience, Vol. 17, No. 11, 1700214, 2017.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Butyrate-Loaded Chitosan/Hyaluronan Nanoparticles: A Suitable Tool for Sustained Inhibition of ROS Release by Activated Neutrophils

    AU - Sacco, Pasquale

    AU - Decleva, Eva

    AU - Tentor, Fabio

    AU - Menegazzi, Renzo

    AU - Borgogna, Massimiliano

    AU - Paoletti, Sergio

    AU - Kristiansen, Kåre Andre

    AU - Vårum, Kjell Morten

    AU - Marsich, Eleonora

    PY - 2017

    Y1 - 2017

    N2 - Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion. Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA. Notably, while the inhibition of neutrophil ROS production by free butyrate declines over time, that of butyrate-loaded chitosan/hyaluronan nanoparticles (B-NPs) is sustained. Additional valuable features of these nanoparticles are inherent ROS scavenger activity, resistance to cell internalization, and mucoadhesiveness. B-NPs appear as promising tools to limit ROS-dependent tissue injury during inflammation. Particularly, by virtue of their mucoadhesiveness, B-NPs administered by enema can be effective in the treatment of inflammatory bowel diseases.

    AB - Tissue damage caused by excessive amounts of neutrophil-derived reactive oxygen species (ROS) occurs in many inflammatory diseases. Butyrate is a short-chain fatty acid (SCFA) with known anti-inflammatory properties, able to modulate several neutrophil functions. Evidence is provided here that butyrate inhibits neutrophil ROS release in a dose and time-dependent fashion. Given the short half-life of butyrate, chitosan/hyaluronan nanoparticles are next designed and developed as controlled release carriers able to provide cells with a long-lasting supply of this SCFA. Notably, while the inhibition of neutrophil ROS production by free butyrate declines over time, that of butyrate-loaded chitosan/hyaluronan nanoparticles (B-NPs) is sustained. Additional valuable features of these nanoparticles are inherent ROS scavenger activity, resistance to cell internalization, and mucoadhesiveness. B-NPs appear as promising tools to limit ROS-dependent tissue injury during inflammation. Particularly, by virtue of their mucoadhesiveness, B-NPs administered by enema can be effective in the treatment of inflammatory bowel diseases.

    U2 - 10.1002/mabi.201700214

    DO - 10.1002/mabi.201700214

    M3 - Journal article

    VL - 17

    JO - Macromolecular Bioscience

    JF - Macromolecular Bioscience

    SN - 1616-5187

    IS - 11

    M1 - 1700214

    ER -