Burden of disease of dietary exposure to acrylamide in Denmark

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Abstract

Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in food have on health. In this study, we estimated the burden of disease (BoD) caused by dietary exposure to AA, using disability adjusted life years (DALY) as health metric.We applied an exposure-based approach and proposed a model of three components: an exposure, health-outcome, and DALY-module. We estimated BoD using two approaches for estimating cancer risk based on toxicological data and two approaches for estimating DALY.In Denmark, 1.8 healthy life years per 100.000 inhabitants are lost each year due to exposure to AA through foods, as estimated by the most conservative approach.This result should be used to inform risk management decisions and for comparison with BoD of other food-borne hazards for prioritizing policies. However, our study shows that careful evaluation of methodological choices and assumptions used in BoD studies is necessary before use in policy making.
Original languageEnglish
JournalFood and Chemical Toxicology
Volume90
Pages (from-to)151-159
Number of pages9
ISSN0278-6915
DOIs
Publication statusPublished - 2016

Keywords

  • Food Science
  • Toxicology
  • Acrylamide
  • Cancer
  • DALY

Cite this

@article{6c767c2027744bf7822a4cbd61dfbb98,
title = "Burden of disease of dietary exposure to acrylamide in Denmark",
abstract = "Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in food have on health. In this study, we estimated the burden of disease (BoD) caused by dietary exposure to AA, using disability adjusted life years (DALY) as health metric.We applied an exposure-based approach and proposed a model of three components: an exposure, health-outcome, and DALY-module. We estimated BoD using two approaches for estimating cancer risk based on toxicological data and two approaches for estimating DALY.In Denmark, 1.8 healthy life years per 100.000 inhabitants are lost each year due to exposure to AA through foods, as estimated by the most conservative approach.This result should be used to inform risk management decisions and for comparison with BoD of other food-borne hazards for prioritizing policies. However, our study shows that careful evaluation of methodological choices and assumptions used in BoD studies is necessary before use in policy making.",
keywords = "Food Science, Toxicology, Acrylamide, Cancer, DALY",
author = "Jakobsen, {Lea Sletting} and Kit Granby and Knudsen, {Vibeke Kildegaard} and Maarten Nauta and Pires, {Sara Monteiro} and Morten Poulsen",
year = "2016",
doi = "10.1016/j.fct.2016.01.021",
language = "English",
volume = "90",
pages = "151--159",
journal = "Food and Chemical Toxicology",
issn = "0278-6915",
publisher = "Pergamon Press",

}

Burden of disease of dietary exposure to acrylamide in Denmark. / Jakobsen, Lea Sletting; Granby, Kit; Knudsen, Vibeke Kildegaard; Nauta, Maarten; Pires, Sara Monteiro; Poulsen, Morten.

In: Food and Chemical Toxicology, Vol. 90, 2016, p. 151-159.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Burden of disease of dietary exposure to acrylamide in Denmark

AU - Jakobsen, Lea Sletting

AU - Granby, Kit

AU - Knudsen, Vibeke Kildegaard

AU - Nauta, Maarten

AU - Pires, Sara Monteiro

AU - Poulsen, Morten

PY - 2016

Y1 - 2016

N2 - Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in food have on health. In this study, we estimated the burden of disease (BoD) caused by dietary exposure to AA, using disability adjusted life years (DALY) as health metric.We applied an exposure-based approach and proposed a model of three components: an exposure, health-outcome, and DALY-module. We estimated BoD using two approaches for estimating cancer risk based on toxicological data and two approaches for estimating DALY.In Denmark, 1.8 healthy life years per 100.000 inhabitants are lost each year due to exposure to AA through foods, as estimated by the most conservative approach.This result should be used to inform risk management decisions and for comparison with BoD of other food-borne hazards for prioritizing policies. However, our study shows that careful evaluation of methodological choices and assumptions used in BoD studies is necessary before use in policy making.

AB - Acrylamide (AA) is a process-contaminant that potentially increases the risk of developing cancer in humans. AA is formed during heat treatment of starchy foods and detected in a wide range of commonly consumed products. Increased focus on risk ranking and prioritization of major causes of disease makes it relevant to estimate the impact that exposure to chemical contaminants and other hazards in food have on health. In this study, we estimated the burden of disease (BoD) caused by dietary exposure to AA, using disability adjusted life years (DALY) as health metric.We applied an exposure-based approach and proposed a model of three components: an exposure, health-outcome, and DALY-module. We estimated BoD using two approaches for estimating cancer risk based on toxicological data and two approaches for estimating DALY.In Denmark, 1.8 healthy life years per 100.000 inhabitants are lost each year due to exposure to AA through foods, as estimated by the most conservative approach.This result should be used to inform risk management decisions and for comparison with BoD of other food-borne hazards for prioritizing policies. However, our study shows that careful evaluation of methodological choices and assumptions used in BoD studies is necessary before use in policy making.

KW - Food Science

KW - Toxicology

KW - Acrylamide

KW - Cancer

KW - DALY

U2 - 10.1016/j.fct.2016.01.021

DO - 10.1016/j.fct.2016.01.021

M3 - Journal article

VL - 90

SP - 151

EP - 159

JO - Food and Chemical Toxicology

JF - Food and Chemical Toxicology

SN - 0278-6915

ER -