Burden-addicted production strains

Peter Rugbjerg; William Kristian Pallisgaard Olsen; Morten Otto Alexander Sommer; Anne Line Tidemand Johansen

Burden-addicted production strains

Peter Rugbjerg (Inventor), William Kristian Pallisgaard Olsen (Inventor), Morten Otto Alexander Sommer (Inventor), Anne Line Tidemand Johansen (Inventor)

Research output: Patent

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Abstract

The invention provides a microbial production cell for synthesis of a product, further comprising a burden-addiction genetic circuit whose expression confers a selective growth and/or survival advantage on those cells that synthesize the product; while limiting proliferation of low- or non-productive escaper cells.

Original language	English
IPC	C12P 21/ 00 A I
Patent number	WO2021160854
Filing date	12/02/2021
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	13/02/2020
Priority number	EP20200157159
Publication status	Published - 19 Aug 2021

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title = "Burden-addicted production strains",

abstract = "The invention provides a microbial production cell for synthesis of a product, further comprising a burden-addiction genetic circuit whose expression confers a selective growth and/or survival advantage on those cells that synthesize the product; while limiting proliferation of low- or non-productive escaper cells.",

author = "Peter Rugbjerg and Olsen, {William Kristian Pallisgaard} and Sommer, {Morten Otto Alexander} and Johansen, {Anne Line Tidemand}",

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language = "English",

type = "Patent",

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AU - Rugbjerg, Peter

AU - Olsen, William Kristian Pallisgaard

AU - Sommer, Morten Otto Alexander

AU - Johansen, Anne Line Tidemand

PY - 2021/8/19

Y1 - 2021/8/19

N2 - The invention provides a microbial production cell for synthesis of a product, further comprising a burden-addiction genetic circuit whose expression confers a selective growth and/or survival advantage on those cells that synthesize the product; while limiting proliferation of low- or non-productive escaper cells.

AB - The invention provides a microbial production cell for synthesis of a product, further comprising a burden-addiction genetic circuit whose expression confers a selective growth and/or survival advantage on those cells that synthesize the product; while limiting proliferation of low- or non-productive escaper cells.

M3 - Patent

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Y2 - 2021/02/12

ER -

Burden-addicted production strains

Abstract

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