Building up cyclodextrins from scratch - templated enzymatic synthesis of cyclodextrins directly from maltose

Dennis Larsen, Sophie Beeren*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Cyclodextrins (CDs) are commercially produced via enzymatic breakdown of starch or amylose. In contrast, we show that cyclodextrins can be synthesised directly from the disaccharide maltose in good yields by exploiting the use of templates to favour the enzymatic build-up of cyclodextrins. Using cyclodextrin glucanotransferase to catalyse reversible transglycosylation, and 1-adamantane carboxylic acid as the template, we can synthesise β-CD from maltose in approximately 70% yield. This work represents a step towards supramolecular control over enzymatic production of complex oligosaccharides from simple building blocks.
Original languageEnglish
JournalChemical Communications
Volume57
Pages (from-to)8456–8460
ISSN1359-7345
DOIs
Publication statusPublished - 2021

Fingerprint Dive into the research topics of 'Building up cyclodextrins from scratch - templated enzymatic synthesis of cyclodextrins directly from maltose'. Together they form a unique fingerprint.

Cite this