TY - JOUR
T1 - Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats
T2 - ESBL—AmpC Producing E. coli as An Example—Challenges and Perspectives
AU - Perestrelo, Sara
AU - Amaro, Ana
AU - Brouwer, Michael S. M.
AU - Clemente, Lurdes
AU - Duarte, Ana Sofia Ribeiro
AU - Kaesbohrer, Annemarie
AU - Karpíšková, Renata
AU - Lopez-Chavarrias, Vicente
AU - Morris, Dearbháile
AU - Prendergast, Deirdre
AU - Pista, Angela
AU - Silveira, Leonor
AU - Skarżyńska, Magdalena
AU - Slowey, Rosemarie
AU - Veldman, Kees T.
AU - Zając, Magdalena
AU - Burgess, Catherine
AU - Alvarez, Julio
PY - 2023
Y1 - 2023
N2 - Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.
AB - Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC β-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.
KW - Escherichia coli
KW - Extended-spectrum beta-lactamase (ESBL)
KW - AmpC beta-lactamase (AmpC)
KW - One Health
KW - Monitoring
U2 - 10.3390/antibiotics12030552
DO - 10.3390/antibiotics12030552
M3 - Journal article
C2 - 36978419
SN - 2079-6382
VL - 12
JO - Antibiotics
JF - Antibiotics
IS - 3
M1 - 552
ER -
