Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

Gregory Severin, Carsten H. Nielsen, Andreas Tue Ingemann Jensen, Jesper Fonslet, Andreas Kjær, Fedor Zhuravlev

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    Abstract

    We present a novel solid-phase based 45Ti radiolabeling methodology and the implementation of 45Ti-PET in titanium-based antineoplastics using the showcase compound [45Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.
    Original languageEnglish
    JournalJournal of Medicinal Chemistry
    Volume58
    Issue number18
    Pages (from-to)7591–7595
    Number of pages5
    ISSN0022-2623
    DOIs
    Publication statusPublished - 2015

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