Breaking the performance ceiling for neoantigen immunogenicity prediction

Hugh O'Brien; Max Salm; Laura Morton; Maciej Szukszto; Felix O'Farrell; Charlotte Boulton; Pablo D. Becker; Yardena Samuels; Charles Swanton; Marc R. Mansour; Sine Reker Hadrup; Sergio A. Quezada

doi:10.1038/s43018-023-00675-z

Breaking the performance ceiling for neoantigen immunogenicity prediction

Hugh O'Brien
, Max Salm^*
, Laura Morton
, Maciej Szukszto
, Felix O'Farrell
, Charlotte Boulton
, Pablo D. Becker
, Yardena Samuels
, Charles Swanton
, Marc R. Mansour
, Sine Reker Hadrup^*
, Sergio A. Quezada^*

^*Corresponding author for this work

Achilles Therapeutics Ltd
University College London
Weizmann Institute of Science
The Francis Crick Institute

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Neoantigen immunogenicity prediction is a burgeoning field with vast potential; however, the shortage of high-quality data and biases in current datasets limit model generalizability. Here we discuss some of the pitfalls that may underly this limited performance and propose a path forward.

Original language	English
Journal	Nature Cancer
Volume	4
Pages (from-to)	1618-1621
ISSN	2662-1347
DOIs	https://doi.org/10.1038/s43018-023-00675-z
Publication status	Published - 2023

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@article{b68898705f8b4dbeb4a31b1a39be8d7b,

title = "Breaking the performance ceiling for neoantigen immunogenicity prediction",

abstract = "Neoantigen immunogenicity prediction is a burgeoning field with vast potential; however, the shortage of high-quality data and biases in current datasets limit model generalizability. Here we discuss some of the pitfalls that may underly this limited performance and propose a path forward.",

author = "Hugh O'Brien and Max Salm and Laura Morton and Maciej Szukszto and Felix O'Farrell and Charlotte Boulton and Becker, \{Pablo D.\} and Yardena Samuels and Charles Swanton and Mansour, \{Marc R.\} and Hadrup, \{Sine Reker\} and Quezada, \{Sergio A.\}",

year = "2023",

doi = "10.1038/s43018-023-00675-z",

language = "English",

volume = "4",

pages = "1618--1621",

journal = "Nature Cancer",

issn = "2662-1347",

publisher = "Nature Research",

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TY - JOUR

T1 - Breaking the performance ceiling for neoantigen immunogenicity prediction

AU - O'Brien, Hugh

AU - Salm, Max

AU - Morton, Laura

AU - Szukszto, Maciej

AU - O'Farrell, Felix

AU - Boulton, Charlotte

AU - Becker, Pablo D.

AU - Samuels, Yardena

AU - Swanton, Charles

AU - Mansour, Marc R.

AU - Hadrup, Sine Reker

AU - Quezada, Sergio A.

PY - 2023

Y1 - 2023

N2 - Neoantigen immunogenicity prediction is a burgeoning field with vast potential; however, the shortage of high-quality data and biases in current datasets limit model generalizability. Here we discuss some of the pitfalls that may underly this limited performance and propose a path forward.

AB - Neoantigen immunogenicity prediction is a burgeoning field with vast potential; however, the shortage of high-quality data and biases in current datasets limit model generalizability. Here we discuss some of the pitfalls that may underly this limited performance and propose a path forward.

UR - https://www.nature.com/articles/s43018-024-00767-4

U2 - 10.1038/s43018-023-00675-z

DO - 10.1038/s43018-023-00675-z

M3 - Journal article

C2 - 38102360

SN - 2662-1347

VL - 4

SP - 1618

EP - 1621

JO - Nature Cancer

JF - Nature Cancer

ER -

Breaking the performance ceiling for neoantigen immunogenicity prediction

Abstract

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