Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2 '-alpha-L-amino-LNA FRET pairs

Kira Astakhova; T. Santhosh Kumar; Meghan A. Campbell; Alexey V. Ustinov; Vladimir A. Korshun; Jesper Wengel

doi:10.1039/c2cc37547h

Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2 '-alpha-L-amino-LNA FRET pairs

Kira Astakhova, T. Santhosh Kumar, Meghan A. Campbell, Alexey V. Ustinov, Vladimir A. Korshun, Jesper Wengel

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Novel pyrene-perylene alpha-L-LNA FRET pairs described herein effectively detect assembly of 2- and 3-way branched DNA nanostructures prepared by postsynthetic microwave-assisted CuAAC click chemistry. The fluorescent signalling of assembly by internally positioned FRET pairs is achieved with low to no fluorescence background signal, remarkably low limit of target detection values and stabilization of the resulting nanostructures.

Original language	English
Journal	Chemical Communications
Volume	49
Issue number	5
Pages (from-to)	511-513
Number of pages	3
ISSN	1359-7345
DOIs	https://doi.org/10.1039/c2cc37547h
Publication status	Published - 2013
Externally published	Yes

Access to Document

10.1039/c2cc37547h

OpenUrl availability

Full text

Cite this

@article{72005070f27b4abcb1f2e61fc1911607,

title = "Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2 '-alpha-L-amino-LNA FRET pairs",

abstract = "Novel pyrene-perylene alpha-L-LNA FRET pairs described herein effectively detect assembly of 2- and 3-way branched DNA nanostructures prepared by postsynthetic microwave-assisted CuAAC click chemistry. The fluorescent signalling of assembly by internally positioned FRET pairs is achieved with low to no fluorescence background signal, remarkably low limit of target detection values and stabilization of the resulting nanostructures.",

author = "Kira Astakhova and Kumar, {T. Santhosh} and Campbell, {Meghan A.} and Ustinov, {Alexey V.} and Korshun, {Vladimir A.} and Jesper Wengel",

year = "2013",

doi = "10.1039/c2cc37547h",

language = "English",

volume = "49",

pages = "511--513",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2 '-alpha-L-amino-LNA FRET pairs

AU - Astakhova, Kira

AU - Kumar, T. Santhosh

AU - Campbell, Meghan A.

AU - Ustinov, Alexey V.

AU - Korshun, Vladimir A.

AU - Wengel, Jesper

PY - 2013

Y1 - 2013

N2 - Novel pyrene-perylene alpha-L-LNA FRET pairs described herein effectively detect assembly of 2- and 3-way branched DNA nanostructures prepared by postsynthetic microwave-assisted CuAAC click chemistry. The fluorescent signalling of assembly by internally positioned FRET pairs is achieved with low to no fluorescence background signal, remarkably low limit of target detection values and stabilization of the resulting nanostructures.

AB - Novel pyrene-perylene alpha-L-LNA FRET pairs described herein effectively detect assembly of 2- and 3-way branched DNA nanostructures prepared by postsynthetic microwave-assisted CuAAC click chemistry. The fluorescent signalling of assembly by internally positioned FRET pairs is achieved with low to no fluorescence background signal, remarkably low limit of target detection values and stabilization of the resulting nanostructures.

U2 - 10.1039/c2cc37547h

DO - 10.1039/c2cc37547h

M3 - Journal article

SN - 1359-7345

VL - 49

SP - 511

EP - 513

JO - Chemical Communications

JF - Chemical Communications

IS - 5

ER -

Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2 '-alpha-L-amino-LNA FRET pairs

Abstract

Access to Document

OpenUrl availability

Fingerprint

Cite this