Branched DNA nanostructures efficiently stabilised and monitored by novel pyrene-perylene 2 '-alpha-L-amino-LNA FRET pairs

Kira Astakhova, T. Santhosh Kumar, Meghan A. Campbell, Alexey V. Ustinov, Vladimir A. Korshun, Jesper Wengel

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Novel pyrene-perylene alpha-L-LNA FRET pairs described herein effectively detect assembly of 2- and 3-way branched DNA nanostructures prepared by postsynthetic microwave-assisted CuAAC click chemistry. The fluorescent signalling of assembly by internally positioned FRET pairs is achieved with low to no fluorescence background signal, remarkably low limit of target detection values and stabilization of the resulting nanostructures.
Original languageEnglish
JournalChemical Communications
Volume49
Issue number5
Pages (from-to)511-513
Number of pages3
ISSN1359-7345
DOIs
Publication statusPublished - 2013
Externally publishedYes

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