Brain tumor vessels—a barrier for drug delivery

Casper Hempel*, Kasper B. Johnsen, Serhii Kostrikov, Petra Hamerlik, Thomas L. Andresen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Cancer treatment remains a challenge due to a high level of intra- and intertumoral heterogeneity and the rapid development of chemoresistance. In the brain, this is further hampered by the blood-brain barrier that reduces passive diffusion of drugs to a minimum. Tumors grow invasively and form new blood vessels, also in brain tissue where remodeling of pre-existing vasculature is substantial. The cancer-associated vessels in the brain are considered leaky and thus could facilitate the transport of chemotherapeutic agents. Yet, brain tumors are extremely difficult to treat, and, in this review, we will address how different aspects of the vasculature in brain tumors contribute to this.
Original languageEnglish
JournalCancer and Metastasis Reviews
Volume39
Pages (from-to)959–968
Number of pages10
ISSN0167-7659
DOIs
Publication statusPublished - 2020

Keywords

  • Blood vessels
  • Blood-brain barrier
  • Brain tumors
  • Drug delivery
  • Glioblastoma

Fingerprint Dive into the research topics of 'Brain tumor vessels—a barrier for drug delivery'. Together they form a unique fingerprint.

Cite this