Brain perfusion CT compared with 15O-H2O PET in patients with primary brain tumours

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Brain perfusion CT compared with 15O-H2O PET in patients with primary brain tumours. / Grüner, Julie Marie; Paamand, Rune; Kosteljanetz, Michael; Broholm, Helle; Højgaard, Liselotte; Law, Ian.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, No. 11, 2012, p. 1691-1701.

Research output: Contribution to journalJournal article – Annual report year: 2012Researchpeer-review

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Grüner, Julie Marie ; Paamand, Rune ; Kosteljanetz, Michael ; Broholm, Helle ; Højgaard, Liselotte ; Law, Ian. / Brain perfusion CT compared with 15O-H2O PET in patients with primary brain tumours. In: European Journal of Nuclear Medicine and Molecular Imaging. 2012 ; Vol. 39, No. 11. pp. 1691-1701.

Bibtex

@article{1974accbca944685b3e906e231b4719c,
title = "Brain perfusion CT compared with 15O-H2O PET in patients with primary brain tumours",
abstract = "Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with 15O-labelled water (15O-H2O).On the same day within a few hours, rCBF was measured in ten adult patients with treatment-na{\"i}ve primary brain tumours, twice using 15O-H2O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared.PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min−1 100 ml−1 for PET and 78.9 ± 41.8 ml min−1 100 ml−1 for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min−1 100 ml−1 for low-grade (WHO I + II) and 81.5 ± 15.4 ml min−1 100 ml−1 for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients.Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and 15O-H2O PET in brain tumours.",
author = "Gr{\"u}ner, {Julie Marie} and Rune Paamand and Michael Kosteljanetz and Helle Broholm and Liselotte H{\o}jgaard and Ian Law",
year = "2012",
doi = "10.1007/s00259-012-2173-1",
language = "English",
volume = "39",
pages = "1691--1701",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Springer",
number = "11",

}

RIS

TY - JOUR

T1 - Brain perfusion CT compared with 15O-H2O PET in patients with primary brain tumours

AU - Grüner, Julie Marie

AU - Paamand, Rune

AU - Kosteljanetz, Michael

AU - Broholm, Helle

AU - Højgaard, Liselotte

AU - Law, Ian

PY - 2012

Y1 - 2012

N2 - Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with 15O-labelled water (15O-H2O).On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using 15O-H2O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared.PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min−1 100 ml−1 for PET and 78.9 ± 41.8 ml min−1 100 ml−1 for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min−1 100 ml−1 for low-grade (WHO I + II) and 81.5 ± 15.4 ml min−1 100 ml−1 for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients.Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and 15O-H2O PET in brain tumours.

AB - Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with 15O-labelled water (15O-H2O).On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using 15O-H2O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared.PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min−1 100 ml−1 for PET and 78.9 ± 41.8 ml min−1 100 ml−1 for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min−1 100 ml−1 for low-grade (WHO I + II) and 81.5 ± 15.4 ml min−1 100 ml−1 for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients.Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and 15O-H2O PET in brain tumours.

U2 - 10.1007/s00259-012-2173-1

DO - 10.1007/s00259-012-2173-1

M3 - Journal article

VL - 39

SP - 1691

EP - 1701

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 11

ER -