Brain perfusion CT compared with 15O-H2O PET in patients with primary brain tumours

Research output: Contribution to journalJournal article – Annual report year: 2012Researchpeer-review

Without internal affiliation

  • Author: Grüner, Julie Marie

    Copenhagen University Hospital, Denmark

  • Author: Paamand, Rune

    Copenhagen University Hospital, Denmark

  • Author: Kosteljanetz, Michael

    Copenhagen University Hospital, Denmark

  • Author: Broholm, Helle

    Copenhagen University Hospital, Denmark

  • Author: Højgaard, Liselotte

    Copenhagen University Hospital

  • Author: Law, Ian

    Copenhagen University Hospital, Denmark

View graph of relations

Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with 15O-labelled water (15O-H2O).On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using 15O-H2O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared.PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min−1 100 ml−1 for PET and 78.9 ± 41.8 ml min−1 100 ml−1 for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min−1 100 ml−1 for low-grade (WHO I + II) and 81.5 ± 15.4 ml min−1 100 ml−1 for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients.Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and 15O-H2O PET in brain tumours.
Original languageEnglish
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume39
Issue number11
Pages (from-to)1691-1701
ISSN1619-7070
DOIs
Publication statusPublished - 2012
Externally publishedYes
CitationsWeb of Science® Times Cited: No match on DOI
Download as:
Download as PDF
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
PDF
Download as HTML
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
HTML
Download as Word
Select render style:
APAAuthorCBE/CSEHarvardMLAStandardVancouverShortLong
Word

ID: 52940712