Abstract
We have been studying brachytherapy planning with the objective of
manimizing the maximum deviation of the delivered dose from
prescribed dose bounds for treatment volumes. A general framework
for optimal treatment planning is presented and the minmax
optimization is formulated as a linear program. Dose rate
calculations are based on the sosimetry formulation of the
American Association of Physicists in Medicine, Task Group 43. We
apply the technique to optimal planning for intravascular
brachytherapy of intimal hyperplasia using ultrasound data and
192Ir seeds. The planning includes determination of an optimal
dwell-time sequence for a train of seeds that deliver ratiation
while stepping through the vessel lesion. The results illustrate
the advantage of this strategy over the common approach of
delivering radiation by positioning a single train of seeds along
the whole lesion.
| Original language | English |
|---|---|
| Journal | Medical Image Analysis |
| Volume | 3 |
| Issue number | 3 |
| Pages (from-to) | 223-236 |
| ISSN | 1361-8415 |
| Publication status | Published - 1999 |