Brachyspira murdochii colitis in pigs

Tim Kåre Jensen, A. S. Christensen, Mette Boye

    Research output: Contribution to journalJournal articleResearchpeer-review


    The weakly beta-hemolytic porcine spirochete Brachyspira murdochii is considered a normal intestinal commensal. In the present study, however, a field case of B murdochii–associated catarrhal colitis was identified in a pig, as characterized by extensive spirochetal colonization of the surface epithelium. Experimentally, 8 weaned pigs were challenged with the B murdochii isolate, reproducing catarrhal colitis in 2 animals. By applying fluorescent in situ hybridization using a species-specific oligonucleotide probe targeting 23S rRNA, B murdochii organisms were found in high numbers and were closely associated with the surface epithelium in the pigs with catarrhal colitis. The results indicate that, when present in high numbers, B murdochii is low pathogenic for pigs.
    Original languageEnglish
    JournalVeterinary Pathology
    Issue number2
    Pages (from-to)334-338
    Publication statusPublished - 2010


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