Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs

Hanne Kristine Møller; Thomas Thymann; Lisbeth Nielsen Fink; Hanne Frokiaer; Anne S. Kvistgaard; Per T. Sangild

doi:10.1017/S0007114510003168

Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs

Hanne Kristine Møller, Thomas Thymann, Lisbeth Nielsen Fink, Hanne Frokiaer, Anne S. Kvistgaard, Per T. Sangild

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Milk contains immunomodulatory compounds that may be important to protect the immature intestine in preterm neonates from harmful inflammatory reactions involved in disorders like necrotising enterocolitis (NEC). We hypothesised that bovine colostrum and milk formulas enriched with sialic acids (SL), gangliosides (Gang) or osteopontin (OPN) would improve gastrointestinal function and NEC resistance in preterm neonates. Forty-seven caesarean-delivered preterm pigs were given total parenteral nutrition for 2 d followed by 1.5 d of enteral feeding. In Expt 1, a control formula was compared with an OPN-enriched formula (n 13), while Expt 2 compared a control formula with bovine colostrum or formulas enriched with Gang or SL (n 4-6). OPN enrichment decreased NEC severity relative to control formula (P

Original language	English
Journal	British Journal of Nutrition
Volume	105
Issue number	1
Pages (from-to)	44-53
ISSN	0007-1145
DOIs	https://doi.org/10.1017/S0007114510003168
Publication status	Published - 2011

Keywords

Necrotising enterocolitis
Milk bioactives
Colostrum
Immunomodulation

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title = "Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs",

abstract = "Milk contains immunomodulatory compounds that may be important to protect the immature intestine in preterm neonates from harmful inflammatory reactions involved in disorders like necrotising enterocolitis (NEC). We hypothesised that bovine colostrum and milk formulas enriched with sialic acids (SL), gangliosides (Gang) or osteopontin (OPN) would improve gastrointestinal function and NEC resistance in preterm neonates. Forty-seven caesarean-delivered preterm pigs were given total parenteral nutrition for 2 d followed by 1.5 d of enteral feeding. In Expt 1, a control formula was compared with an OPN-enriched formula (n 13), while Expt 2 compared a control formula with bovine colostrum or formulas enriched with Gang or SL (n 4-6). OPN enrichment decreased NEC severity relative to control formula (P",

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year = "2011",

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language = "English",

volume = "105",

pages = "44--53",

journal = "British Journal of Nutrition",

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Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs. / Møller, Hanne Kristine; Thymann, Thomas; Fink, Lisbeth Nielsen; Frokiaer, Hanne; Kvistgaard, Anne S.; Sangild, Per T.

In: British Journal of Nutrition, Vol. 105, No. 1, 2011, p. 44-53.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Frokiaer, Hanne

AU - Kvistgaard, Anne S.

AU - Sangild, Per T.

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AB - Milk contains immunomodulatory compounds that may be important to protect the immature intestine in preterm neonates from harmful inflammatory reactions involved in disorders like necrotising enterocolitis (NEC). We hypothesised that bovine colostrum and milk formulas enriched with sialic acids (SL), gangliosides (Gang) or osteopontin (OPN) would improve gastrointestinal function and NEC resistance in preterm neonates. Forty-seven caesarean-delivered preterm pigs were given total parenteral nutrition for 2 d followed by 1.5 d of enteral feeding. In Expt 1, a control formula was compared with an OPN-enriched formula (n 13), while Expt 2 compared a control formula with bovine colostrum or formulas enriched with Gang or SL (n 4-6). OPN enrichment decreased NEC severity relative to control formula (P

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KW - Milk bioactives

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KW - Immunomodulation

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