Bovine colostrum is superior to enriched formulas in stimulating intestinal function and necrotising enterocolitis resistance in preterm pigs

Hanne Kristine Møller, Thomas Thymann, Lisbeth Nielsen Fink, Hanne Frokiaer, Anne S. Kvistgaard, Per T. Sangild

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Milk contains immunomodulatory compounds that may be important to protect the immature intestine in preterm neonates from harmful inflammatory reactions involved in disorders like necrotising enterocolitis (NEC). We hypothesised that bovine colostrum and milk formulas enriched with sialic acids (SL), gangliosides (Gang) or osteopontin (OPN) would improve gastrointestinal function and NEC resistance in preterm neonates. Forty-seven caesarean-delivered preterm pigs were given total parenteral nutrition for 2 d followed by 1.5 d of enteral feeding. In Expt 1, a control formula was compared with an OPN-enriched formula (n 13), while Expt 2 compared a control formula with bovine colostrum or formulas enriched with Gang or SL (n 4-6). OPN enrichment decreased NEC severity relative to control formula (P
    Original languageEnglish
    JournalBritish Journal of Nutrition
    Volume105
    Issue number1
    Pages (from-to)44-53
    ISSN0007-1145
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Necrotising enterocolitis
    • Milk bioactives
    • Colostrum
    • Immunomodulation

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