Bone phenotypes in rheumatology – there is more to bone than just bone

Christian S. Thudium*, Signe Holm Nielsen, Samra Sardar, Ali Mobasheri, Willem Evert van Spil, Rik Lories, Kim Henriksen, Anne Christine Bay-Jensen, Morten A. Karsdal

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, all have one clear common denominator; an altered turnover of bone. However, this may be more complex than a simple change in bone matrix and mineral turnover. While these diseases share a common tissue axis, their manifestations in the area of pathology are highly diverse, ranging from sclerosis to erosion of bone in different regions. The management of these diseases will benefit from a deeper understanding of the local versus systemic effects, the relation to the equilibrium of the bone balance (i.e., bone formation versus bone resorption), and the physiological and pathophysiological phenotypes of the cells involved (e.g., osteoblasts, osteoclasts, osteocytes and chondrocytes). For example, the process of endochondral bone formation in chondrocytes occurs exists during skeletal development and healthy conditions, but also in pathological conditions. This review focuses on the complex molecular and cellular taxonomy of bone in the context of rheumatological diseases that alter bone matrix composition and maintenance, giving rise to different bone turnover phenotypes, and how biomarkers (biochemical markers) can be applied to potentially describe specific bone phenotypic tissue profiles.
Original languageEnglish
Article number789
JournalBMC Musculoskeletal Disorders
Number of pages20
Publication statusPublished - 2020


  • Osteoarthritis
  • Psoriatic arthritis
  • Rheumatoid arthritis
  • Ankylosing spondylitis
  • Endotype
  • Matrix
  • Biomarker
  • Biochemical marker
  • Phenotype
  • Bone
  • Remodeling
  • Endochondral
  • Therapeutic


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