Blu-Ray-based micromechanical characterization platform for biopolymer degradation assessment

Research output: Contribution to journalJournal article – Annual report year: 2016Researchpeer-review

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Blu-Ray-based micromechanical characterization platform for biopolymer degradation assessment. / Casci Ceccacci, Andrea; Chen, Ching-Hsiu; Hwu, En-Te; Morelli, Lidia; Bose-Goswami, Sanjukta; Bosco, Filippo; Schmid, Silvan; Boisen, Anja.

In: Sensors and Actuators B: Chemical, Vol. 241, 2017, p. 1303–1309.

Research output: Contribution to journalJournal article – Annual report year: 2016Researchpeer-review

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@article{4d9117044dd84b23b427dc09bf9c6b05,
title = "Blu-Ray-based micromechanical characterization platform for biopolymer degradation assessment",
abstract = "Degradable biopolymers are used as carrier materials in drug delivery devices. A complete understanding of their degradation behaviour is thus crucial in the design of new delivery systems. Here we combine a reliable method, based on spray coated micromechanical resonators and a disposable microfluidic chip, to characterize biopolymer degradation under the action of enzymes in controlled flow condition. The sensing platform is based on the mechanics and optics from a Blu-Ray player, which automatically localize individual sensors within the array, and sequentially measure and record the resonance frequency of up to twelve resonators within 4 min. Such fast and automated measuring technology, combined with the use of thin polymers layers in the degradation experiments, allows to reduce the experimental time needed for degradation studies from 6 weeks to 8 h. We first present a full characterization of sensor properties and then perform degradation studies of poly(lactic-co-glycolic acid) (PLGA) in steady flow for three different enzyme concentrations. The degradation has been performed in liquid environment. Before each resonator measurement, the measuring chamber has been automatically dried, since the resonator characteristics are much approved when measuring in air compared to liquid. The obtained degradation profiles are comparable to profiles obtained by conventional approaches, which have shown to require up to 6 weeks of experimental time frame.",
keywords = "Biopolymer degradation, Sensing system, Micromechanical resonator, Blu-ray, Instrumentation, High throughput sensing system",
author = "{Casci Ceccacci}, Andrea and Ching-Hsiu Chen and En-Te Hwu and Lidia Morelli and Sanjukta Bose-Goswami and Filippo Bosco and Silvan Schmid and Anja Boisen",
year = "2017",
doi = "10.1016/j.snb.2016.09.190",
language = "English",
volume = "241",
pages = "1303–1309",
journal = "Sensors and Actuators B: Chemical",
issn = "0925-4005",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Blu-Ray-based micromechanical characterization platform for biopolymer degradation assessment

AU - Casci Ceccacci, Andrea

AU - Chen, Ching-Hsiu

AU - Hwu, En-Te

AU - Morelli, Lidia

AU - Bose-Goswami, Sanjukta

AU - Bosco, Filippo

AU - Schmid, Silvan

AU - Boisen, Anja

PY - 2017

Y1 - 2017

N2 - Degradable biopolymers are used as carrier materials in drug delivery devices. A complete understanding of their degradation behaviour is thus crucial in the design of new delivery systems. Here we combine a reliable method, based on spray coated micromechanical resonators and a disposable microfluidic chip, to characterize biopolymer degradation under the action of enzymes in controlled flow condition. The sensing platform is based on the mechanics and optics from a Blu-Ray player, which automatically localize individual sensors within the array, and sequentially measure and record the resonance frequency of up to twelve resonators within 4 min. Such fast and automated measuring technology, combined with the use of thin polymers layers in the degradation experiments, allows to reduce the experimental time needed for degradation studies from 6 weeks to 8 h. We first present a full characterization of sensor properties and then perform degradation studies of poly(lactic-co-glycolic acid) (PLGA) in steady flow for three different enzyme concentrations. The degradation has been performed in liquid environment. Before each resonator measurement, the measuring chamber has been automatically dried, since the resonator characteristics are much approved when measuring in air compared to liquid. The obtained degradation profiles are comparable to profiles obtained by conventional approaches, which have shown to require up to 6 weeks of experimental time frame.

AB - Degradable biopolymers are used as carrier materials in drug delivery devices. A complete understanding of their degradation behaviour is thus crucial in the design of new delivery systems. Here we combine a reliable method, based on spray coated micromechanical resonators and a disposable microfluidic chip, to characterize biopolymer degradation under the action of enzymes in controlled flow condition. The sensing platform is based on the mechanics and optics from a Blu-Ray player, which automatically localize individual sensors within the array, and sequentially measure and record the resonance frequency of up to twelve resonators within 4 min. Such fast and automated measuring technology, combined with the use of thin polymers layers in the degradation experiments, allows to reduce the experimental time needed for degradation studies from 6 weeks to 8 h. We first present a full characterization of sensor properties and then perform degradation studies of poly(lactic-co-glycolic acid) (PLGA) in steady flow for three different enzyme concentrations. The degradation has been performed in liquid environment. Before each resonator measurement, the measuring chamber has been automatically dried, since the resonator characteristics are much approved when measuring in air compared to liquid. The obtained degradation profiles are comparable to profiles obtained by conventional approaches, which have shown to require up to 6 weeks of experimental time frame.

KW - Biopolymer degradation

KW - Sensing system

KW - Micromechanical resonator

KW - Blu-ray

KW - Instrumentation

KW - High throughput sensing system

U2 - 10.1016/j.snb.2016.09.190

DO - 10.1016/j.snb.2016.09.190

M3 - Journal article

VL - 241

SP - 1303

EP - 1309

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

SN - 0925-4005

ER -