Bistability in autoimmune diseases

Nicolas Rapin, Erik Mosekilde, Ole Lund

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Abstract

Autoimmune diseases damage host tissue, which, in turn, may trigger a stronger immune response. Systems characterized by such positive feedback loops can display co-existing stable steady states. In a mathematical model of autoimmune disease, one steady state may correspond to the healthy state and another to an autoimmune steady state characterized by widespread tissue damage and immune activation. We show how a triggering event may move the system from the healthy to the autoimmune state and how transient immunosuppressive treatment can move the system back to the healthy state.
Original languageEnglish
JournalAutoimmunity
Volume44
Issue number4
Pages (from-to)256-260
ISSN0891-6934
DOIs
Publication statusPublished - 2011

Keywords

  • Mathematical modeling
  • Bistability
  • Autoimmunity

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