Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A

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Abstract

Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe substitutes, however, remains largely unknown. Here, we investigated the potential of bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF), bisphenol S (BPS), and 4‐cumylphenol (4‐CP) to affect lipid and hormone levels in 3 T3‐L1 cells. We found that BPB, BPE, BPF, BPS, and 4‐CP all affected lipid accumulation and leptin levels to the same extent and potencies as BPA. Based on these and other results, we conclude that these BPA analogues and 4‐CP most likely will elicit similar effects on adipocytes as BPA. Using them to substitute BPA in products should be done with caution.
Original languageEnglish
JournalEnvironmental Toxicology
Number of pages10
ISSN1520-4081
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • Adipocytes
  • BPA analogues
  • Leptin
  • Obesity
  • PPARy

Cite this

@article{8b3c4db8604c493a9bf88c40658e1095,
title = "Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A",
abstract = "Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe substitutes, however, remains largely unknown. Here, we investigated the potential of bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF), bisphenol S (BPS), and 4‐cumylphenol (4‐CP) to affect lipid and hormone levels in 3 T3‐L1 cells. We found that BPB, BPE, BPF, BPS, and 4‐CP all affected lipid accumulation and leptin levels to the same extent and potencies as BPA. Based on these and other results, we conclude that these BPA analogues and 4‐CP most likely will elicit similar effects on adipocytes as BPA. Using them to substitute BPA in products should be done with caution.",
keywords = "Adipocytes, BPA analogues, Leptin, Obesity, PPARy",
author = "{Ramskov Tetzlaff}, {Cecilie Nethe} and Terje Svingen and Vinggaard, {Anne Marie} and Rosenmai, {Anna Kjerstine} and Camilla Taxvig",
year = "2020",
doi = "10.1002/tox.22889",
language = "English",
journal = "Environmental Toxicology",
issn = "1520-4081",
publisher = "JohnWiley & Sons, Inc.",

}

TY - JOUR

T1 - Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A

AU - Ramskov Tetzlaff, Cecilie Nethe

AU - Svingen, Terje

AU - Vinggaard, Anne Marie

AU - Rosenmai, Anna Kjerstine

AU - Taxvig, Camilla

PY - 2020

Y1 - 2020

N2 - Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe substitutes, however, remains largely unknown. Here, we investigated the potential of bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF), bisphenol S (BPS), and 4‐cumylphenol (4‐CP) to affect lipid and hormone levels in 3 T3‐L1 cells. We found that BPB, BPE, BPF, BPS, and 4‐CP all affected lipid accumulation and leptin levels to the same extent and potencies as BPA. Based on these and other results, we conclude that these BPA analogues and 4‐CP most likely will elicit similar effects on adipocytes as BPA. Using them to substitute BPA in products should be done with caution.

AB - Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe substitutes, however, remains largely unknown. Here, we investigated the potential of bisphenol B (BPB), bisphenol E (BPE), bisphenol F (BPF), bisphenol S (BPS), and 4‐cumylphenol (4‐CP) to affect lipid and hormone levels in 3 T3‐L1 cells. We found that BPB, BPE, BPF, BPS, and 4‐CP all affected lipid accumulation and leptin levels to the same extent and potencies as BPA. Based on these and other results, we conclude that these BPA analogues and 4‐CP most likely will elicit similar effects on adipocytes as BPA. Using them to substitute BPA in products should be done with caution.

KW - Adipocytes

KW - BPA analogues

KW - Leptin

KW - Obesity

KW - PPARy

U2 - 10.1002/tox.22889

DO - 10.1002/tox.22889

M3 - Journal article

C2 - 31820560

JO - Environmental Toxicology

JF - Environmental Toxicology

SN - 1520-4081

ER -