Biotic acts of antibiotics

Rustam I. Aminov

Research output: Contribution to journalJournal articleResearchpeer-review

107 Downloads (Pure)

Abstract

Biological functions of antibiotics are not limited to killing. The most likely function of antibiotics in natural microbial ecosystems is signaling. Does this signaling function of antibiotics also extend to the eukaryotic - in particular mammalian - cells? In this review, the host modulating properties of three classes of antibiotics (macrolides, tetracyclines, and β-lactams) will be briefly discussed. Antibiotics can be effective in treatment of a broad spectrum of diseases and pathological conditions other than those of infectious etiology and, in this capacity, may find widespread applications beyond the intended antimicrobial use. This use, however, should not compromise the primary function antibiotics are used for. The biological background for this inter-kingdom signaling is also discussed.
Original languageEnglish
JournalFrontiers in Microbiology
Volume4
Number of pages16
ISSN1664-302X
DOIs
Publication statusPublished - 2013
Externally publishedYes

Fingerprint Dive into the research topics of 'Biotic acts of antibiotics'. Together they form a unique fingerprint.

Cite this