Biotechnological domestication of pseudomonads using synthetic biology

Pablo Ivan Nikel, Esteban Martínez-García, Victor de Lorenzo

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Much of contemporary synthetic biology research relies on the use of bacterial chassis for plugging-in and plugging-out genetic circuits and new-to-nature functionalities. However, the microorganisms that are the easiest to manipulate in the laboratory are often suboptimal for downstream industrial applications, which can involve physicochemical stress and harsh operating conditions. In this Review, we advocate the use of environmental Pseudomonas strains as model organisms that are pre-endowed with the metabolic, physiological and stress-endurance traits that are demanded by current and future synthetic biology and biotechnological needs.
Original languageEnglish
JournalNature Reviews. Microbiology
Volume12
Issue number5
Pages (from-to)368-379
Number of pages12
ISSN1740-1526
DOIs
Publication statusPublished - 2014
Externally publishedYes

Cite this